Association of biofilm formation and methicillin-resistance with accessory gene regulator (agr) loci in Greek Staphylococcus aureus clones

被引：26
作者：
Ikonomidis, Alexandros [1 ]
Vasdeki, Afroditi [1 ]
Kristo, Ioulia [1 ]
Maniatis, Antonios N. [1 ]
Tsakris, Athanassios [3 ]
Malizos, Konstantinos N. [2 ]
Pournaras, Spyros [1 ]
机构：
[1] Univ Thessaly, Sch Med, Dept Microbiol, Univ Hosp Larissa,Mezourlo Area, Larisa, Greece
[2] Univ Thessaly, Sch Med, Dept Orthopaed, Mezourlo Area, Larisa, Greece
[3] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece
来源：
MICROBIAL PATHOGENESIS | 2009年 / 47卷 / 06期
关键词：
Staphylococci; Adhesion; Quorum sensing; Haemolysis; agr Group II; REDUCED SUSCEPTIBILITY; GROUP-II; VANCOMYCIN; ADHERENCE; STRAINS;
D O I：
10.1016/j.micpath.2009.09.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pathogenicity of Staphylococcus aureus is coordinated by the accessory gene regulator (agr) system. Previous studies suggested that agr Group 11 methicillin-resistant S. aureus (MRSA), a polymorphism that has been associated with moderate response to vancomycin, may also be related with overproduction of biofilm. In a hospital environment with endemic occurrence of MRSA, the distribution of agr groups and their association with biofilm formation was investigated. Forty-two MRSA and 32 methicillin-susceptible S. aureus (MSSA) isolates were tested and had derived from 10 genotypes and 8 clonal complexes. agr Groups I, II and IV were evenly distributed among MRSAs and MSSAs but agr Group III was not detected. agr Group II MRSAs showed significantly higher levels of biofilm production in comparison with MRSAs of the remaining agr groups as well as with all three agr groups of MSSAs. These findings suggest that agr Group II is simultaneously associated with methicillin-resistance and biofilm overproduction in a region with endemic MRSA. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：341 / 344
页数：4
相关论文
共 15 条
  • [1] agr-Genotyping and transcriptional analysis of biofilm-producing Staphylococcus aureus
    Cafiso, Viviana
    Bertuccio, Taschia
    Santagati, Maria
    Demelio, Vanessa
    Spina, Daniela
    Nicoletti, Giuseppe
    Stefani, Stefania
    [J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2007, 51 (01): : 220 - 227
  • [2] ADHERENCE OF COAGULASE-NEGATIVE STAPHYLOCOCCI TO PLASTIC TISSUE-CULTURE PLATES - A QUANTITATIVE MODEL FOR THE ADHERENCE OF STAPHYLOCOCCI TO MEDICAL DEVICES
    CHRISTENSEN, GD
    SIMPSON, WA
    YOUNGER, JJ
    BADDOUR, LM
    BARRETT, FF
    MELTON, DM
    BEACHEY, EH
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 22 (06) : 996 - 1006
  • [3] Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci
    Dunman, PM
    Murphy, E
    Haney, S
    Palacios, D
    Tucker-Kellogg, G
    Wu, S
    Brown, EL
    Zagursky, RJ
    Shlaes, D
    Projan, SJ
    [J]. JOURNAL OF BACTERIOLOGY, 2001, 183 (24) : 7341 - 7353
  • [4] *EUR ANT RES SURV, 2002, ANN REP EARSS 2001
  • [5] The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?
    Fitzpatrick, F
    Humphreys, H
    O'Gara, JP
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (12) : 967 - 973
  • [6] Genetic relatedness between methicillin-susceptible and methicillin-resistant Staphylococcus aureus:: results of a national survey
    Hallin, M.
    Denis, O.
    Deplano, A.
    De Mendonca, R.
    De Ryck, R.
    Rottiers, S.
    Struelens, M. J.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (03) : 465 - 472
  • [7] In Vitro and In Vivo Evaluations of Oxacillin Efficiency against mecA-Positive Oxacillin-Susceptible Staphylococcus aureus
    Ikonomidis, Alexandros
    Michail, George
    Vasdeki, Afroditi
    Labrou, Maria
    Karavasilis, Vasilis
    Stathopoulos, Constantinos
    Maniatis, Antonios N.
    Pournaras, Spyros
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (11) : 3905 - 3908
  • [8] Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (Alleles), and human disease
    Jarraud, S
    Mougel, C
    Thioulouse, J
    Lina, G
    Meugnier, H
    Forey, F
    Nesme, X
    Etienne, J
    Vandenesch, F
    [J]. INFECTION AND IMMUNITY, 2002, 70 (02) : 631 - 641
  • [9] Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide
    Maira-Litrán, T
    Kropec, A
    Abeygunawardana, C
    Joyce, J
    Mark, G
    Goldmann, DA
    Pier, GB
    [J]. INFECTION AND IMMUNITY, 2002, 70 (08) : 4433 - 4440
  • [10] Accessory gene regulator group II polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy
    Moise-Broder, PA
    Sakoulas, G
    Eliopoulos, GM
    Schentag, JJ
    Forrest, A
    Moellering, RC
    [J]. CLINICAL INFECTIOUS DISEASES, 2004, 38 (12) : 1700 - 1705
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