Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane

被引：404

作者：

Xu, WH

Liu, YG

Wang, S

McDonald, T

Van Eyk, JE

Sidor, A

O'Rourke, B ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Mol Cardiobiol, Baltimore, MD 21205 USA

[2] Otsuka Maryland Res Inst, Maryland Res Labs, Rockville, MD 20850 USA

[3] Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada

来源：

SCIENCE | 2002年 / 298卷 / 5595期

关键词：

D O I：

10.1126/science.1074360

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate sensitive K+ channel (mitoK(ATP)), is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoK(Ca)) of guinea pig ventricular cells. MitoK(Ca) significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoK(Ca) protected hearts against infarction.

引用

页码：1029 / 1033

页数：6

共 29 条

[1] Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells [J].