Lyngbyastatins 8-10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena

被引：69

作者：

Kwan, Jason C. ^{[1
]}

Taori, Kanchan ^{[1
]}

Paul, Valerie J. ^{[2
]}

Luesch, Hendrik ^{[1
]}

机构：

[1] Univ Florida, Dept Med Chem, Gainesville, FL 32610 USA

[2] Smithsonian Marine Stn, Ft Pierce, FL 34949 USA

来源：

MARINE DRUGS | 2009年 / 7卷 / 04期

关键词：

lyngbyastatins; cyanobacteria; Lyngbya semiplena; cyclic depsipeptides; elastase inhibitors; SERINE-PROTEASE INHIBITORS; MICROCYSTIS-AERUGINOSA; POTENT; N-GREATER-THAN-3; CONFERVOIDES; CYTOTOXIN; PEPTIDES; SPECTRA; NMR;

D O I：

10.3390/md7040528

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8-10 (1-3). The structures of 1-3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1-3 are closely related to lyngbyastatins 4-7. Like the latter compounds, we found 1-3 to inhibit porcine pancreatic elastase, with IC50 values of 123 nM, 210 nM and 120 nM, respectively.

引用

页码：528 / 538

页数：11

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