A two-step synthesis of ferrocenyl pyrazole and pyrimidine derivatives based on carbonylative Sonogashira coupling of iodoferrocene

被引：27

作者：

Feher, Csaba ^{[1
]}

Kuik, Arpad ^{[1
]}

Mark, Laszlo ^{[2
]}

Kollar, Laszlo ^{[3
]}

Skoda-Foeldes, Rita ^{[1
]}

机构：

[1] Univ Pannonia, Inst Chem, Dept Organ Chem, H-8201 Veszprem, Hungary

[2] Univ Pecs, Sch Med, Inst Biochem & Med Chem, H-7624 Pecs, Hungary

[3] Univ Pecs, Dept Inorgan Chem, H-7624 Pecs, Hungary

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2009年 / 694卷 / 25期

基金：

美国国家科学基金会;

关键词：

Carbonylation; Ferrocene; Pyrazole; Pyrimidine; Palladium; REGIOSELECTIVE SYNTHESIS; TERMINAL ACETYLENES; ALPHA-KETOAMIDES; X-RAY; COMPLEXES; 5-FERROCENYLPYRIMIDINE; HETEROCYCLES; REACTIVITY; HYDRAZINES; IMIDAZOLE;

D O I：

10.1016/j.jorganchem.2009.08.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new method for the synthesis of 3-substituted-1-ferrocenyl-2-propyn-1-ones was developed involving carbonylative Sonogashira coupling of iodoferrocene with terminal acetylenes. New ferrocenyl 1,3,5-trisubstituted pyrazoles and 2,4,6-trisubstituted pyrimidines were obtained by the addition-cyclocondensation reaction of the alkynones with hydrazines and guanidinium salts, respectively. The products were obtained with moderate to excellent yields and were characterised with various spectroscopic methods (H-1 NMR, C-13 NMR IR, MS). (C) 2009 Elsevier B. V. All rights reserved.

引用

页码：4036 / 4041

页数：6

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