Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

被引：25

作者：

Barras, Alexandre ^{[1
]}

Sauvage, Felix ^{[2
]}

de Hoon, Ines ^{[1
,2
]}

Braeckmans, Kevin ^{[2
]}

Hua, Dawei ^{[2
]}

Buvat, Gaetan ^{[1
]}

Fraire, Juan C. ^{[2
]}

Lethien, Christophe ^{[1
]}

Sebag, J. ^{[3
,4
]}

Harrington, Michael ^{[5
]}

Abderrahmani, Amar ^{[1
]}

Boukherroub, Rabah ^{[1
]}

De Smedt, Stefaan ^{[2
]}

Szunerits, Sabine ^{[1
]}

机构：

[1] Univ Polytech Hauts de France, Cent Lille, Univ Lille, CNRS,UMR IEMN 8520, F-59000 Lille, France

[2] Univ Ghent, Lab Gen Biochem & Phys Pharm, Fac Pharmaceut Sci, B-9000 Ghent, Belgium

[3] VMR Inst Vitreous Macula Retina, Huntington Beach, CA 92647 USA

[4] Univ Calif Los Angeles, Doheny Eye Inst, Los Angeles, CA 90033 USA

[5] Huntington Mem Res Inst, Pasadena, CA USA

来源：

NANOSCALE HORIZONS | 2021年 / 6卷 / 06期

基金：

欧盟地平线“2020”;

关键词：

CONTRAST SENSITIVITY; HIGH-EFFICIENCY; QUANTIFICATION; FIBRILLATION; VITREOLYSIS; DERIVATIVES; VITRECTOMY; NANODOTS; EFFICACY; SAFETY;

D O I：

10.1039/d1nh00157d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Common in myopia and aging, vitreous opacities arise from clumped collagen fibers within the vitreous body that cast shadows on the retina, appearing as 'floaters' to the patient. Vitreous opacities degrade contrast sensitivity function and can cause significant impairment in vision-related quality-of-life, representing an unmet and underestimated medical need. One therapeutic approach could be the use of versatile light-responsive nanostructures which (i) interfere with the formation of collagen fibers and/or (ii) destroy aggregates of vitreous collagen upon pulsed-laser irradiation at low fluences. In this work, the potential of positively and negatively charged carbon quantum dots (CQDs) to interfere with the aggregation of type I collagen is investigated. We demonstrate that fibrillation of collagen I is prevented most strongly by positively charged CQDs (CQDs-2) and that pulsed-laser illumination allowed to destroy type I collagen aggregates and vitreous opacities (as obtained from patients after vitrectomy) treated with CQDs-2.

引用

页码：449 / 461

页数：13

共 52 条

[11] Biocompatible and blood-brain barrier permeable carbon dots for inhibition of Aβ fibrillation and toxicity, and BACE1 activity [J].

Han, Xu ;

Jing, Zhifeng ;

Wu, Wei ;

Zou, Bing ;

Peng, Zhili ;

Ren, Pengyu ;

Wikramanayake, Athula ;

Lu, Zhongmin ;

Leblanc, Roger M. .

NANOSCALE, 2017, 9 (35) :12862-12866

[12] Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure [J].

Hill, Stephen A. ;

Benito-Alifonso, David ;

Davis, Sean A. ;

Morgan, David J. ;

Berry, Monica ;

Galan, M. Carmen .

SCIENTIFIC REPORTS, 2018, 8

[13] Synthesis of nanodiamond derivatives carrying amino functions and quantification by a modified Kaiser test [J].

Jarre, Gerald ;

Heyer, Steffen ;

Memmel, Elisabeth ;

Meinhardt, Thomas ;

Krueger, Anke .

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014, 10 :2729-2737

[14] Disintegration of collagen fibrils by Glucono-δ-lactone: An implied lead for disintegration of fibrosis [J].

Jayamani, Jayaraman ;

Reddy, R. Ravikanth ;

Madhan, Balaraman ;

Shanmugam, Ganesh .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 107 :175-185

[15] Super-Cationic Carbon Quantum Dots Synthesized from Spermidine as an Eye Drop Formulation for Topical Treatment of Bacterial Keratitis [J].

Jian, Hong-Jyuan ;

Wu, Ren-Siang ;

Lin, Tzu-Yu ;

Li, Yu-Jia ;

Lin, Han-Jia ;

Harroun, Scott G. ;

Lai, Jui-Yang ;

Huang, Chih-Ching .

ACS NANO, 2017, 11 (07) :6703-6716

[16] Optimizing the Synthesis of Red-Emissive Nitrogen-Doped Carbon Dots for Use in Bioimaging [J].

Karakocak, Bedia Begum ;

Liang, Jue ;

Kavadiya, Shalinee ;

Berezin, Mikhail Y. ;

Biswas, Pratim ;

Ravi, Nathan .

ACS APPLIED NANO MATERIALS, 2018, 1 (07) :3682-3692

[17] Label-Free Detection of Single Living Bacteria via Electrochemical Collision Event [J].

Lee, Ji Young ;

Kim, Byung-Kwon ;

Kang, Mijeong ;

Park, Jun Hui .

SCIENTIFIC REPORTS, 2016, 6

[18] High-Oxygen-Content Carbon Dots as a High-Efficiency Inhibitor of Human Insulin Aggregation [J].

Li, Chen-Qiao ;

Liu, Xing-Yu ;

Li, Shu-Lan ;

Jiang, Peng ;

Jiang, Feng-Lei ;

Liu, Yi .

ACS APPLIED BIO MATERIALS, 2019, 2 (09) :4067-4076

[19] Nontoxic Carbon Dots Potently Inhibit Human Insulin Fibrillation [J].

Li, Shanghao ;

Wang, Lingyu ;

Chusuei, Charles C. ;

Suarez, Valentina M. ;

Blackwelder, Patrica L. ;

Micic, Miodrag ;

Orbulescu, Jhony ;

Leblanc, Roger M. .

CHEMISTRY OF MATERIALS, 2015, 27 (05) :1764-1771

[20] Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus [J].

Loczechin, Aleksandra ;

Seron, Karin ;

Barras, Alexandre ;

Giovanelli, Emerson ;

Belouzard, Sandrine ;

Chen, Yen-Ting ;

Metzler-Nolte, Nils ;

Boukherroub, Rabah ;

Dubuisson, Jean ;

Szunerits, Sabine .

ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (46) :42964-42974

← 1 2 3 4 5 6 →