Thyroid Stem Cells and Cancer

被引：42
|
作者：
Klonisch, Thomas [1 ,2 ]
Hoang-Vu, Cuong [3 ]
Hombach-Klonisch, Sabine [1 ,4 ]
机构：
[1] Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 0J9, Canada
[2] Univ Manitoba, Fac Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB R3E 0J9, Canada
[3] Univ Halle Wittenberg, Fac Med, Surg Clin, Halle, Germany
[4] Univ Manitoba, Fac Med, Dept Obstet Gynecol & Reprod Sci, Winnipeg, MB R3E 0J9, Canada
来源：
THYROID | 2009年 / 19卷 / 12期
关键词：
FETAL-MATERNAL MICROCHIMERISM; IMATINIB MESYLATE GLEEVEC; FIBRONECTIN MESSENGER-RNA; FIBROBLAST GROWTH-FACTORS; GERM LAYER FORMATION; THYROCYTE-LIKE CELLS; GENE-EXPRESSION; SIDE-POPULATION; IN-VITRO; BONE-MARROW;
D O I：
10.1089/thy.2009.1604
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Thyroid gland development and function are essential for life, and recent findings indicate the presence of stem/progenitor cells within the thyroid gland as a potential source of tissue regeneration and cancer formation. Summary: This review summarizes the current knowledge on early differentiation of thyroid cells from embryonic stem cells and highlights exciting concepts and recent novel findings on adult thyroid stem/progenitor cells in the normal thyroid gland and in thyroid cancer. Other potential sources and markers of stem/progenitor cells in the thyroid include bone marrow, microchimerism, and embryological remnant-derived multifocal solid cell nests. Finally, we discuss new therapeutic strategies that target thyroid cancer stem cells. Conclusions: Thyroid stem/progenitor cell populations are present in the normal and diseased thyroid gland. Advances in normal and cancer thyroid stem cell biology will be essential for future targeted therapies.
引用
收藏
页码：1303 / 1315
页数：13
相关论文
共 50 条
  • [1] Cancer Stem Cells in the Thyroid
    Nagayama, Yuji
    Shimamura, Mika
    Mitsutake, Norisato
    FRONTIERS IN ENDOCRINOLOGY, 2016, 7
  • [2] Thyroid cancer stem cells
    Lin, Reigh-Yi
    NATURE REVIEWS ENDOCRINOLOGY, 2011, 7 (10) : 609 - 616
  • [3] Thyroid stem cells - danger or resource?
    Gibelli, B.
    El-Fattah, A. M. A.
    Giugliano, G.
    Proh, M.
    Grosso, E.
    ACTA OTORHINOLARYNGOLOGICA ITALICA, 2009, 29 (06) : 290 - 295
  • [4] Thyroid cancer development and progression: emerging role of cancer stem cells
    Malaguarnera, R.
    Morcavallo, A.
    Giuliano, S.
    Belfiore, A.
    MINERVA ENDOCRINOLOGICA, 2012, 37 (02) : 103 - 115
  • [5] Normal vs cancer thyroid stem cells: the road to transformation
    Zane, M.
    Scavo, E.
    Catalano, V.
    Bonanno, M.
    Todaro, M.
    De Maria, R.
    Stassi, G.
    ONCOGENE, 2016, 35 (07) : 805 - 815
  • [6] Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells
    Hombach-Klonisch, Sabine
    Natarajan, Suchitra
    Thanasupawat, Thatchawan
    Medapati, Manoj
    Pathak, Alok
    Ghavami, Saeid
    Klonisch, Thomas
    FRONTIERS IN ENDOCRINOLOGY, 2014, 5
  • [7] Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: Characterization of resistant cells
    Zheng, Xuqin
    Cui, Dai
    Xu, Shuhang
    Brabant, Georg
    Derwahl, Michael
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2010, 37 (02) : 307 - 315
  • [8] Phenotypic Characterization of Metastatic Anaplastic Thyroid Cancer Stem Cells
    Li, Wen
    Reeb, Ashley N.
    Sewell, William A.
    Elhomsy, George
    Lin, Reigh-Yi
    PLOS ONE, 2013, 8 (05):
  • [9] The Emerging Cell Biology of Thyroid Stem Cells
    Davies, Terry F.
    Latif, Rauf
    Minsky, Noga C.
    Ma, Risheng
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (09) : 2692 - 2702
  • [10] Characterisation of normal and cancer stem cells: One experimental paradigm for two kinds of stem cells
    Mayol, Jean-Francois
    Loeuillet, Corinne
    Herodin, Francis
    Wion, Didier
    BIOESSAYS, 2009, 31 (09) : 993 - 1001
12345