Update on long QT syndrome

被引：25

作者：

Neira, Victor ^{[1
]}

Enriquez, Andres ^{[1
]}

Simpson, Chris ^{[1
]}

Baranchuk, Adrian ^{[1
]}

机构：

[1] Queens Univ, Div Cardiol, Kingston, ON, Canada

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 2019年 / 30卷 / 12期

关键词：

electrocardiography; long QT; QT interval; torsades de pointes; CARDIAC SYMPATHETIC DENERVATION; NA+ CHANNEL BLOCKADE; TORSADES-DE-POINTES; HIGH-RISK PATIENTS; BETA-BLOCKERS; T-WAVE; ARRHYTHMIC EVENTS; SCN5A MUTATIONS; MOLECULAR-BASIS; HEART-RATE;

D O I：

10.1111/jce.14227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Long QT syndrome (LQTS) is an inherited disorder characterized by a prolonged QT interval in the 12-lead electrocardiogram and increased risk of malignant arrhythmias in patients with a structurally normal heart. Since its first description in the 1950s, advances in molecular genetics have greatly improved our understanding of the cause and mechanisms of this disease. Sixteen genes linked to LQTS have been described and genetic testing had become an integral part of the diagnosis and risk stratification. This article provides an updated review of the genetic basis, diagnosis, and clinical management of LQTS.

引用

页码：3068 / 3078

页数：11

共 77 条

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