LncRNA LHFPL3-AS1 Promotes Oral Squamous Cell Carcinoma Growth and Cisplatin Resistance Through Targeting miR-362-5p/CHSY1 Pathway

被引：15
|
作者：
Li, Jiandong [1 ]
Xu, Xiaohu [1 ]
Zhang, Dandan [1 ]
Lv, Han [1 ]
Lei, Xin [1 ]
机构：
[1] Shenzhen Longhua Dist Cent Hosp, Dept Stomatol, Shenzhen 518000, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2021年 / 14卷
关键词：
oral squamous cell carcinoma; LHFPL3-AS1; miR-362-5p; CHSY1; CANCER METASTASIS; PROLIFERATION; INVASION; AXIS;
D O I：
10.2147/OTT.S298679
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Oral squamous cell carcinoma (OSCC) is a common oral cancer. The current study aims to elucidate the potential roles of long noncoding RNA (lncRNA) LHFPL3-AS1 in OSCC development. Methods: Gene expression was measured by qRT-PCR in tumor tissues and cell lines. Loss-of-function assays were performed to analyze the effects of LHFPL3-AS1 on malignant behaviors. Bioinformatics analysis was conducted to explore the downstream signaling pathway of LHFPL3-AS1 in OSCC. Results: LHFPL3-AS1 was highly expressed in OSCC tissues and cell lines. LHFPL3-AS1 was upregulated in cisplatin-resistant tumor cell lines. LHFPL3-AS1 level was correlated with survival rate. LHFPL3-AS1 knockdown suppressed OSCC proliferation, migration and invasion. LHFPL3-AS1 downregulation reduced cisplatin resistance of OSCC cells. LHFPL3-AS1 was the competing endogenous RNA (ceRNA) for miR-194-5p to enhance CHSY1 expression. Conclusion: LHFPL3-AS1/miR-362-5p/CHSY1 signaling pathway plays essential roles in regulating OSCC development and cisplatin resistance.
引用
收藏
页码：2293 / 2300
页数：8
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