LncRNA LHFPL3-AS1 Promotes Oral Squamous Cell Carcinoma Growth and Cisplatin Resistance Through Targeting miR-362-5p/CHSY1 Pathway

被引：15
|
作者：
Li, Jiandong [1 ]
Xu, Xiaohu [1 ]
Zhang, Dandan [1 ]
Lv, Han [1 ]
Lei, Xin [1 ]
机构：
[1] Shenzhen Longhua Dist Cent Hosp, Dept Stomatol, Shenzhen 518000, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2021年 / 14卷
关键词：
oral squamous cell carcinoma; LHFPL3-AS1; miR-362-5p; CHSY1; CANCER METASTASIS; PROLIFERATION; INVASION; AXIS;
D O I：
10.2147/OTT.S298679
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Oral squamous cell carcinoma (OSCC) is a common oral cancer. The current study aims to elucidate the potential roles of long noncoding RNA (lncRNA) LHFPL3-AS1 in OSCC development. Methods: Gene expression was measured by qRT-PCR in tumor tissues and cell lines. Loss-of-function assays were performed to analyze the effects of LHFPL3-AS1 on malignant behaviors. Bioinformatics analysis was conducted to explore the downstream signaling pathway of LHFPL3-AS1 in OSCC. Results: LHFPL3-AS1 was highly expressed in OSCC tissues and cell lines. LHFPL3-AS1 was upregulated in cisplatin-resistant tumor cell lines. LHFPL3-AS1 level was correlated with survival rate. LHFPL3-AS1 knockdown suppressed OSCC proliferation, migration and invasion. LHFPL3-AS1 downregulation reduced cisplatin resistance of OSCC cells. LHFPL3-AS1 was the competing endogenous RNA (ceRNA) for miR-194-5p to enhance CHSY1 expression. Conclusion: LHFPL3-AS1/miR-362-5p/CHSY1 signaling pathway plays essential roles in regulating OSCC development and cisplatin resistance.
引用
收藏
页码：2293 / 2300
页数：8
相关论文
共 50 条
  • [11] LncRNA HOXA11-AS Promotes Proliferation and Cisplatin Resistance of Oral Squamous Cell Carcinoma by Suppression of miR-214-3p Expression
    Wang, Xiaoyan
    Li, Hong
    Shi, Jing
    BIOMED RESEARCH INTERNATIONAL, 2019, 2019
  • [12] miR-379-5p regulates the proliferation, cell cycle, and cisplatin resistance of oral squamous cell carcinoma cells by targeting ROR1
    Meng, Lei
    Du, Yanlin
    Deng, Banglian
    Duan, Yinzhong
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2023, 15 (03): : 1626 - 1639
  • [13] lncRNA TUG1 promotes the development of oral squamous cell carcinoma by regulating the MAPK signaling pathway by sponging miR-593-3p
    Jiang, Lei
    Zhou, Bing
    Fu, Dongjie
    Cheng, Bo
    CELL CYCLE, 2022, 21 (17) : 1856 - 1866
  • [14] MiR-362-5p, Which Is Regulated by Long Non-Coding RNA MBNL1-AS1, Promotes the Cell Proliferation and Tumor Growth of Bladder Cancer by Targeting QKI
    Wei, Xiaosong
    Wang, Beibei
    Wang, Qi
    Yang, Xiaoming
    Yang, Yang
    Fang, Zhiwei
    Yi, Chengzhi
    Shi, Lei
    Fan, Xin
    Tao, Jin
    Guo, Yufeng
    Song, Dongkui
    FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [15] LncRNA FERIL4 Promotes Oral Squamous Cell Carcinoma Progression via Targeting miR-133a-5p/Prx1 Axis
    Zhang, Nan
    Zeng, Lingfang
    Wang, Shouyi
    Wang, Ronghua
    Yang, Rui
    Jin, Zuolin
    Tao, Hong
    ONCOTARGETS AND THERAPY, 2021, 14 : 795 - 806
  • [16] LncRNA PVT1 Enhances Proliferation and Cisplatin Resistance via Regulating miR-194-5p/HIF1a Axis in Oral Squamous Cell Carcinoma
    Wang, Fang
    Ji, Xin
    Wang, Jingjing
    Ma, Xiangrui
    Yang, Yong
    Zuo, Jinhua
    Cui, Jun
    ONCOTARGETS AND THERAPY, 2020, 13 : 243 - 252
  • [17] LncRNA TTN-AS1 promotes the progression of oral squamous cell carcinoma via miR-411-3p/NFAT5 axis
    Su-Wei Fu
    Yan Zhang
    Shen Li
    Zhi-Yan Shi
    Juan Zhao
    Qing-Li He
    Cancer Cell International, 20
  • [18] LncRNA TTN-AS1 promotes the progression of oral squamous cell carcinoma via miR-411-3p/NFAT5 axis
    Fu, Su-Wei
    Zhang, Yan
    Li, Shen
    Shi, Zhi-Yan
    Zhao, Juan
    He, Qing-Li
    CANCER CELL INTERNATIONAL, 2020, 20 (01)
  • [19] RETRACTED: LncRNA INHBA-AS1 promotes cell growth, migration, and invasion of oral squamous cell carcinoma by sponging miR-143-3p (Retracted Article)
    Ma, W-Q
    Chen, J.
    Fang, W.
    Yang, X-Q
    Zhu, A.
    Zhang, D.
    Zhong, H-L
    Yang, B.
    Luo, Z.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (04) : 1821 - 1828
  • [20] FOXM1-Activated LINC01094 Promotes Clear Cell Renal Cell Carcinoma Development via MicroRNA 224-5p/CHSY1
    Jiang, Yufeng
    Zhang, Haimin
    Li, Wei
    Yan, Yang
    Yao, Xudong
    Gu, Wenyu
    MOLECULAR AND CELLULAR BIOLOGY, 2020, 40 (03)
12345