Relationship of HIV Status and Fatigue, Cardiorespiratory Fitness, Myokines, and Physical Activity

被引：6

作者：

Webel, Allison R. ^{[1
]}

Jenkins, Trevor ^{[2
,3
]}

Longenecker, Christopher T. ^{[2
,3
]}

Vest, Marianne ^{[2
]}

Davey, Christine Horvat ^{[1
]}

Currie, Jackson ^{[1
]}

Darrah, Rebecca ^{[1
]}

Litman, Paul ^{[1
]}

de Oliveira, Vitor Hugo Fernando

Josephson, Richard A. ^{[2
,3
]}

机构：

[1] Case Western Reserve Univ, Frances Payne Bolton Sch Nursing, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland, Med Ctr, Harrington Heart & Vasc Inst, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Cleveland, OH USA

来源：

JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE | 2019年 / 30卷 / 04期

基金：

美国国家卫生研究院;

关键词：

cardiovascular; fatigue; self-management intervention; muscle strength; people living with HIV; SUDDEN CARDIAC DEATH; SCIENTIFIC STATEMENT; CARDIOVASCULAR RISK; SKELETAL-MUSCLE; PHENX TOOLKIT; EXERCISE; ASSOCIATION; HEALTH; INFECTION; DISEASE;

D O I：

10.1097/JNC.0000000000000022

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

People living with HIV (PLWH) experience high rates of fatigue, which can be improved with physical activity. We examined relationships between HIV infection, fatigue, cardiorespiratory fitness, physical activity, and myokines. Twenty PLWH and 20 HIV-uninfected adults completed a fatigue assessment, a maximal cardiometabolic exercise test, serum measures of myokines, and wore an accelerometer for 7 days. Measures were completed at baseline, 3 months, and 6 months. At baseline, PLWH had more fatigue (4.7 +/- 2.6 vs. 2.8 +/- 2.5, p = .01) and higher peak ventilatory efficiency (VE/VCO2; 33 +/- 5.5 vs. 30.2 +/- 2.5; p = .06). Half of PLWH engaged in at least one 10-minute bout of physical activity in the previous week, compared with control subjects (65%). Over time, HIV infection and fibroblast growth factor 21 were associated with fatigue (p < .05). People living with HIV have more fatigue and a higher ventilatory efficiency; expression of fibroblast growth factor 21 may underpin this relationship.

引用

页码：392 / 404

页数：13

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