An efficient route to 1,8-dioxo-octahydroxanthenes and -decahydroacridines using a sulfated zirconia catalyst

被引：46

作者：

Kahandal, Sandeep S. ^{[1
]}

Burange, Anand S. ^{[2
]}

Kale, Sandip R. ^{[3
]}

Prinsen, Pepijn ^{[4
]}

Luque, Rafael ^{[4
]}

Jayaram, Radha V. ^{[5
]}

机构：

[1] BN Bandodkar Coll Sci, Dept Chem, Thana, India

[2] Wilson Coll Chowpatty, Dept Chem, Bombay, Maharashtra, India

[3] SIES, Coll Arts Sci & Commerce, Dept Chem, Bombay, Maharashtra, India

[4] Univ Cordoba, Dept Quim Organ, Ediftcio Marie Curie C-3,Ctra Nnal 4-A,Km 396, E-14014 Cordoba, Spain

[5] Inst Chem Technol, Dept Chem, Mumbai, Maharashtra, India

来源：

CATALYSIS COMMUNICATIONS | 2017年 / 97卷

关键词：

1,8-dioxo-octahydroxanthenes; 1,8-dioxo-decahydroacridines; Sulfated zirconia; Heterogeneous catalyst; POTENTIAL ANTITUMOR AGENTS; DERIVATIVES; ACID; CONDENSATION; DIACRIDINES; ALDEHYDES;

D O I：

10.1016/j.catcom.2017.03.017

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Sulfated zirconia results to be a very efficient catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxo-decahydroacridines without tedious work-up procedures. While 1,8-dioxo-octahydroxanthenes are prepared from aldehyde and 5,5-dimethyl-1,3-cyclohexenedione (dimedone), 1,8-dioxo-decahydroacridines are prepared from this reactant mixture with amines. This method provides a mild catalytic protocol for the synthesis of functionalized xanthene and acridine derivatives. The catalysts were characterized by XRD, FT-IR, TGA-DSC, SEM-EDAX and surface acidity and showed excellent re-usability up to 6 consecutive cycles.

引用

页码：138 / 145

页数：8

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