Type I Interferons and Natural Killer Cell Regulation in Cancer

被引：121
作者：
Mueller, Lena [1 ]
Aigner, Petra [1 ]
Stoiber, Dagmar [1 ,2 ]
机构：
[1] Ludwig Boltzmann Inst Canc Res, Vienna, Austria
[2] Med Univ Vienna, Ctr Physiol & Pharmacol, Inst Pharmacol, Vienna, Austria
来源：
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
关键词：
type I interferon; interferon signaling; natural killer cells; tumor surveillance; innate immunity; tumor microenvironment; anticancer therapy; APOPTOSIS-INDUCING LIGAND; ANTITUMOR IMMUNE-RESPONSES; HEMATOPOIETIC STEM-CELLS; DENDRITIC CELLS; NK-CELLS; T-CELL; DISTINCT REQUIREMENTS; SUPPRESSOR-CELLS; TUMOR-CELLS; ALPHA;
D O I：
10.3389/fimmu.2017.00304
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type I interferons (IFNs) are known to mediate antitumor effects against several tumor types and have therefore been commonly used in clinical anticancer treatment. However, how IFN signaling exerts its beneficial effects is only partially understood. The clinically relevant activity of type I IFNs has been mainly attributed to their role in tumor immune surveillance. Different mechanisms have been postulated to explain how type I IFNs stimulate the immune system. On the one hand, they modulate innate immune cell subsets such as natural killer (NK) cells. On the other hand, type I IFNs also influence adaptive immune responses. Here, we review evidence for the impact of type I IFNs on immune surveillance against cancer and highlight the role of NK cells therein.
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页数：11
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