Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)

被引：156

作者：

Loizzo, Monica Rosa ^{[1
]}

Said, Ataa ^{[1
]}

Tundis, Rosa ^{[1
]}

Rashed, Khaled ^{[1
]}

Statti, Giancarlo Antonio ^{[1
]}

Hufner, Antje ^{[1
]}

Menichini, Francesco ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharmaceut Sci, I-87036 Arcavacata Di Rende, CS, Italy

来源：

PHYTOTHERAPY RESEARCH | 2007年 / 21卷 / 01期

关键词：

Ailanthus excelsa (Roxb); flavonoids; angiotensin converting enzyme (ACE); hypertension;

D O I：

10.1002/ptr.2008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In our screening program for antihypertensive properties of plants, the leaves of Ailanthus excelsa (Roxb), a plant used in Egyptian traditional medicine, were analysed. Chromatographic separation of A. excelsa MeOH extract yielded six flavonoids for the first time from this species, namely apigenin, luteolin, kaempferol-3-O-alpha-arabinopyranoside, kaempferol-3-O-beta-galactopyranoside, quereetin-3-O-alpha-arabinopyranoside and luteolin-70-beta-glucopyranoside. The in vitro hypotensive activities of the MeOH extract and the isolated compounds were elucidated. All the flavonoids tested exhibited ACE inhibitory activity, in particular the most active compound was kaempferol-3-O-beta-galactopyranoside with an IC50, value of 260 mu m. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：32 / 36

页数：5

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