Bioavailability and Antioxidant Effects of a Xanthone-Rich Mangosteen (Garcinia mangostana) Product in Humans

被引:106
作者
Kondo, Miwako [1 ]
Zhang, Liliang [1 ]
Ji, Hongping [2 ]
Kou, Yan [2 ]
Ou, Boxin [1 ]
机构
[1] Brunswick Labs, Norton, MA 02766 USA
[2] Brunswick Labs China, Jiangsu, Peoples R China
关键词
Aloe vera; antioxidant; bioavailability; green tea; mangosteen; alpha-mangostin; multivitamin; ORAC; VITAMIN-C; VEGETABLE INTAKE; HEART-DISEASE; FRUIT; PREVENTION; RISK; CONSUMPTION; FLUORESCEIN; CANCER; JUICES;
D O I
10.1021/jf901012f
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Oxidative damage is involved in many chronic; diseases including those cited as the major causes of death in Western societies such as cardiovascular disorders and cancer. Antioxidants may prevent these degenerative processes by various mechanisms including the scavenging of free radicals. Intake of antioxidant supplements is associated with preventing oxidative damages. This study investigated the absorption and antioxidant effects of a xanthone-rich mangosteen liquid in healthy human volunteers after the acute consumption of 59 mL of the supplement. The liquid contained mangosteen, aloe vera, green tea, and multivitamins. Results indicated that alpha-mangostin and vitamins B-2 and B-5 were bioavailable, with observed C-max at t(max) of around 1 h. The antioxidant capacity measured with the oxygen radical absorbance capacity (ORAC) assay was increased with a maximum effect of 18% after 2 h, and the increased antioxidant level lasted at least 4 In. Overall, this study demonstrated the bioavailability of antioxidants from a xanthone-rich mangosteen product and its in vivo antioxidant effects.
引用
收藏
页码:8788 / 8792
页数:5
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