Hyperbaric oxygenation attenuates renal ischemia-reperfusion injury in rats

被引：21
作者：
Gurer, A.
Ozdogan, M.
Gomceli, I.
Demirag, A.
Gulbahar, O.
Arikok, T.
Kulacoglu, H.
Dundar, K.
Ozlem, N.
机构：
[1] Yeditepe Univ Hosp, Dept Surg, TR-34752 Istanbul, Turkey
[2] Yeditepe Univ Hosp, Dept Transplantat, TR-34752 Istanbul, Turkey
来源：
TRANSPLANTATION PROCEEDINGS | 2006年 / 38卷 / 10期
关键词：
D O I：
10.1016/j.transproceed.2006.10.184
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. Oxygen-derived free radicals play an important role in ischemia-reperfusion injury (IR). Hyperbaric oxygenation (HO) decreases free radical production. The aim of this study was to determine the effect of HO treatment on renal ischemia-reperfusion injury in rats. Methods. Rats were divided into four groups. All groups underwent right nephrectomy. Group I served as the control group; group II had left renal ischemia-reperfusion; group III was pretreated with HO; and group IV, ischemia-reperfusion and HO pretreatment. Tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured, and histopathologic damage scored. Results. HO pretreatment significantly decreased tissue MDA levels and histopathologic scores among rats with IR. There was an increased GSH in HO-pretreated rats with IR; however, the difference was not significant. Conclusion. HO prior to ischemia displayed a beneficial effect on renal IR by reducing oxygen radical peroxidation of lipid membranes.
引用
收藏
页码：3337 / 3340
页数：4
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