Oxygenation of 2,3-dihydroindoles

被引：26
作者：
Slätt, J
Bergman, J
机构：
[1] Karolinska Inst, Unit Organ Chem, Dept Biosci, SE-14157 Huddinge, Sweden
[2] Sodertorn Univ Coll, SE-14157 Huddinge, Sweden
来源：
TETRAHEDRON | 2002年 / 58卷 / 45期
关键词：
isatogen; 2,3-dihydroindoles; quinhydrones;
D O I：
10.1016/S0040-4020(02)01198-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Isatogens (3-oxo-3H-indole 1-oxides) possess interesting biological properties and development of a general method to construct these derivatives has now been developed. Indolines (2,3-dihydroindoles) and isatogens have been prepared in an efficient route starting from indoles substituted in position 2. Reduction of the 2-substituted indoles was performed with tin and hydrochloric acid to give racemic indolines, which were converted to isatogens by 3-chloroperoxybenzoic acid (m-CPBA). (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9187 / 9191
页数：5
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