Thymidine phosphorylase in cancer aggressiveness and chemoresistance

被引：33

作者：

Furukawa, Tatsuhiko ^{[1
,2
]}

Tabata, Sho ^{[3
]}

Yamamoto, Masatatsu ^{[1
]}

Kawahara, Kohichi ^{[1
]}

Shinsato, Yoshinari ^{[1
]}

Minami, Kentaro ^{[1
]}

Shimokawa, Michiko ^{[1
]}

Akiyama, Shin-ichi ^{[4
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Mol Oncol, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Ctr Res Adv Diag & Therapy Canc, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan

[3] Keio Univ, Inst Adv Biosci, 246-2 Mizukami, Tsuruoka, Yamagata 9970052, Japan

[4] Natl Kyushu Canc Ctr, Clin Res Ctr, Minami Ku, 3-1-1 Notame, Fukuoka, Fukuoka 8111395, Japan

来源：

PHARMACOLOGICAL RESEARCH | 2018年 / 132卷

关键词：

Thymidine phosphorylase; Thymidine catabolism; Angiogenesis; 2-deoxy-n-ribose; ROS; NF-kappa B; 5-FU; Capecitabine; TFTD; 2-deoxy-o-ribose-5-phosphate aldolase; Glycolytic pathway; CELL-GROWTH-FACTOR; METASTATIC COLORECTAL-CANCER; BREAST-CANCER; ANGIOGENIC FACTORS; FACTOR/THYMIDINE PHOSPHORYLASE; URIDINE PHOSPHORYLASE; PREDICTIVE MARKERS; GASTRIC-CARCINOMA; COLON-CANCER; EXPRESSION;

D O I：

10.1016/j.phrs.2018.03.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thymidine phosphorylase (TP) is a rate-limiting enzyme in thymidine catabolism. TP has several important roles in biological and pharmacological mechanisms; importantly TP acts as an angiogenic factor and one of metabolic enzymes of fluoro-pyrimidine anticancer agents and modifies inflammation. Improving our understanding of the characteristics and functions of TP has led to the development of novel TP-based anticancer therapies. We recently reported that TP-dependent thymidine catabolism contributes to tumour survival in low nutrient conditions and the pathway from thymidine to the glycolysis cascade is affected in the context of physiological and metabolic conditions. In this review, we describe recent advancement in our understanding of TP, with a focus on cancer cell biology and the pharmacology of pyrimidine analogue anticancer agents. This review provides comprehensive understanding of the molecular mechanism of TP function in cancer.

引用

页码：15 / 20

页数：6

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