Immunotherapy for Merkel cell carcinoma

被引：21
作者：
Angeles, Christina V. [1 ]
Sabel, Michael S. [1 ]
机构：
[1] Michigan Med, Dept Surg, Ann Arbor, MI USA
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2021年 / 123卷 / 03期
关键词：
checkpoint inhibitor; immunology; skin cancer; POLYOMAVIRUS INFECTION; AVELUMAB; EXPRESSION; SURVIVAL; EFFICACY; IMMUNITY; VIRUS;
D O I：
10.1002/jso.26319
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Merkel cell carcinoma (MCC) is an aggressive form of skin cancer which, while chemosensitive, has high rates of relapse and chemoresistance, limiting the impact of chemotherapy. An immunogenic tumor, the management of advanced MCC has changed dramatically with the introduction of checkpoint inhibitors. This review will focus on the impact of immunotherapy in unresectable and metastatic MCC, ongoing research in the adjuvant and neoadjuvant settings, and future directions of immune-based strategies for this challenging cancer.
引用
收藏
页码：775 / 781
页数：7
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