Genetics of obesity in humans

被引：353
作者：
Farooqi, I. Sadaf
O'Rahilly, Stephen
机构：
[1] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England
[2] Univ Cambridge, Addenbrookes Hosp, Dept Clin & Biochem, Cambridge CB2 2QQ, England
来源：
ENDOCRINE REVIEWS | 2006年 / 27卷 / 07期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1210/er.2006-0040
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Considerable attention has focused on deciphering the hypothalamic pathways that mediate the behavioral and metabolic effects of leptin. We and others have identified several single gene defects that disrupt the molecules in the leptin-melanocortin pathway causing severe obesity in humans. In this review, we consider these human monogenic obesity syndromes and discuss how far the characterization of these patients has informed our understanding of the physiological role of leptin and the melanocortins in the regulation of human body weight and neuroendocrine function.
引用
收藏
页码：710 / 718
页数：9
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