Association of IL-15 Polymorphisms with Bone Mineral Density in Postmenopausal Korean Women

被引：10

作者：

Koh, Jung-Min ^{[3
,4
]}

Oh, Bermseok ^{[5
,6
]}

Ha, Mi-Hyun ^{[3
]}

Cho, Kyu-Woan ^{[7
]}

Lee, Jong-Young ^{[5
]}

Park, Byung Lae ^{[8
]}

Shin, Hyoung Doo ^{[8
,9
]}

Bae, Myung-Ae ^{[10
]}

Kim, Hyun-Ju ^{[3
]}

Hong, Jung Min ^{[3
]}

Kim, Tae-Ho ^{[3
]}

Shin, Hong-In ^{[2
]}

Lee, Seung Hun ^{[3
,4
]}

Kim, Ghi Su ^{[3
,4
]}

Kim, Shin-Yoon ^{[1
,3
]}

Park, Eui Kyun ^{[2
,3
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, Taegu 700712, South Korea

[2] Kyungpook Natl Univ, Sch Dent, Dept Pathol & Regenerat Med, Taegu 700412, South Korea

[3] Kyungpook Natl Univ Hosp, Skeletal Dis Genome Res Ctr, Taegu 700412, South Korea

[4] Univ Ulsan, Coll Med, Asan Med Ctr, Div Endocrinol & Metab, Seoul 138736, South Korea

[5] Natl Inst Hlth, Natl Genome Res Inst, Seoul 122701, South Korea

[6] Kyung Hee Univ, Sch Med, Dept Biomed Engn, Seoul 130702, South Korea

[7] Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Internal Med, Jinju 660701, South Korea

[8] SNP Genet Inc, Dept Genet Epidemiol, Seoul 110834, South Korea

[9] Sogang Univ, Dept Life Sci, Seoul 121742, South Korea

[10] Korea Res Inst Chem Technol, Drug Discovery Div, Ctr Metab Syndrome Therapeut, Taejon 301832, South Korea

来源：

CALCIFIED TISSUE INTERNATIONAL | 2009年 / 85卷 / 05期

关键词：

IL-15; Osteoporosis; Bone mineral density; Single-nucleotide polymorphism; SINGLE-NUCLEOTIDE POLYMORPHISMS; RHEUMATOID-ARTHRITIS; INSULIN-RESISTANCE; LOW BMD; OSTEOPOROSIS; FRACTURE; RISK; GENE; INTERLEUKIN-15; EXPRESSION;

D O I：

10.1007/s00223-009-9290-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-15 (IL-15) has been suggested to participate in bone metabolism by stimulating osteoclast differentiation and mediating inflammatory bone loss. This study investigated the effect of IL-15 gene polymorphisms on the bone mineral density (BMD) and bone fracture rates of postmenopausal women. Sequencing of the IL-15 gene in 24 Koreans revealed 16 single-nucleotide polymorphisms (SNPs), of which five were selected for further study. Postmenopausal Korean women (n = 844) were genotyped for these SNPs, and their BMDs and risk of fractures were assessed. It was found that the +20A > G, +13467C > A, +13653A > T, and +13815A > T IL-15 gene polymorphisms were significantly associated with the BMD of the lumbar spine and femoral neck and that their effects were gene-dose dependent. BMD was reduced when the minor allele of +13467A and +13653T or the common allele of +20A and +13815A was present. Haplotype (ht) analyses revealed that ht1 (GCAT) and ht2 (AATA) were associated with BMD of the lumbar spine and femoral neck. However, there was no association between the risk of fracture and IL-15 SNPs or hts. These results suggest that the +20A > G, +13467C > A, +13653A > T, and +13815A > T SNPs in the IL-15 gene affect BMD and, thus, could be genetic markers of osteoporosis.

引用

页码：369 / 378

页数：10

共 48 条

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