Chemogenomics: Bridging a drug discovery gap

被引：23

作者：

Bleicher, KH ^{[1
]}

机构：

[1] F Hoffmann La Roche Ltd, Div Pharmaceut, CH-4070 Basel, Switzerland

来源：

CURRENT MEDICINAL CHEMISTRY | 2002年 / 9卷 / 23期

关键词：

target identification; target validation; library design; virtual screening; chemogenomics;

D O I：

10.2174/0929867023368728

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the Successful completion of the human genome sequencing and the resulting plethora of genetic information now available novel technologies and applications have to be established to translate the huge amount of data generated into successful biological and biomedical research programs. The integration of various drug discovery disciplines within the parallel quest for novel targets and new molecular entities has meanwhile given rise to a quite popular term in pharmaceutical research named "chemogenomics". This review article gives an overview of the disciplines involved in this field and discusses the possible implications of this novel paradigm in drug discovery for the near future.

引用

页码：2077 / 2084

页数：8

共 58 条

[1] From sequence to phenotype:: Reverse genetics in Drosophila melanogaster [J].

Adams, MD ;

Sekelsky, JJ .

NATURE REVIEWS GENETICS, 2002, 3 (03) :189-198

[2]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[3]

Balkenhohl F, 1996, ANGEW CHEM INT EDIT, V35, P2289

[4]

BARNARD JM, 2000, VIRTUAL SCREENING BI, P59

[5] Protein-based virtual screening of chemical databases. 1. Evaluation of different docking/scoring combinations [J].

Bissantz, C ;

Folkers, G ;

Rognan, D .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (25) :4759-4767

[6]

Bohm H.J., 2000, VIRTUAL SCREENING BI

[7] Structure-based library design:: molecular modelling merges with combinatorial chemistry [J].

Böhm, HJ ;

Stahl, M .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (03) :283-286

[8] Protein and antibody arrays and their medical applications [J].

Cahill, DJ .

JOURNAL OF IMMUNOLOGICAL METHODS, 2001, 250 (1-2) :81-91

[9] Chemogenomic approaches to drug discovery - Commentary [J].

Caron, PR ;

Mullican, MD ;

Mashal, RD ;

Wilson, KP ;

Su, MS ;

Murcko, MA .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2001, 5 (04) :464-470

[10] Structure-based screening of low-affinity compounds [J].

Carr, R ;

Jhoti, H .

DRUG DISCOVERY TODAY, 2002, 7 (09) :522-527

← 1 2 3 4 5 6 →