Molecular Resolution Imaging of Protein Molecules in Liquid Using Frequency Modulation Atomic Force Microscopy

被引：34

作者：

Yamada, Hirofumi ^{[1
]}

Kobayashi, Kei ^{[2
]}

Fukuma, Takeshi

Hirata, Yoshiki ^{[3
]}

Kajita, Teruyuki ^{[1
]}

Matsushige, Kazumi ^{[1
]}

机构：

[1] Kyoto Univ, Dept Elect Sci & Engn, Kyoto 6158510, Japan

[2] Kyoto Univ, Innovat Collaborat Ctr, Kyoto 6158520, Japan

[3] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058566, Japan

来源：

APPLIED PHYSICS EXPRESS | 2009年 / 2卷 / 09期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

BACTERIORHODOPSIN; GROEL;

D O I：

10.1143/APEX.2.095007

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We demonstrated molecular resolution imaging of biological samples such as bacteriorhodopsin protein molecules in purple membrane and isolated chaperonin (GroEL) protein molecules, both adsorbed on mica using frequency modulation atomic force microscope (FM-AFM) in liquid. We also showed that the frequency noise of FM-AFM in liquid can be greatly reduced by the reduction of the noise-equivalent deflection of an optical beam deflection sensor. (C) 2009 The Japan Society of Applied Physics

引用

页数：3

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