Innate immune defense in visceral leishmaniasis: Cytokine mediated protective role by allogeneic effector cell

被引：13
作者：
Manna, Partha Pratim [1 ]
Chakrabarti, Ganes [2 ]
Bandyopadhyay, Santu [2 ]
机构：
[1] Banaras Hindu Univ, Dept Zool, Varanasi 221005, Uttar Pradesh, India
[2] Indian Inst Chem Biol, Div Infect Dis & Immunol, Kolkata, India
来源：
VACCINE | 2010年 / 28卷 / 03期
关键词：
Leishmania; NK cell; TNF-alpha; Adoptive cell therapy; TUMOR-NECROSIS-FACTOR; TNF RECEPTOR P55; MICE LACKING TNF; INTERFERON-GAMMA; FACTOR-ALPHA; IFN-GAMMA; IN-VIVO; RESISTANCE; INFECTION; TRANSPLANTATION;
D O I：
10.1016/j.vaccine.2009.10.053
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antileishmanial role of mouse splenic natural killer (NK) cell was studied in allogeneic condition. In vitro data indicates that NK cells of allogeneic (C57BL/6, H2(b)) non-leishmania exposed mouse have strong antileishmanial effect against Leishmania donovani infected BALB/c (H2(d)) macrophages Physical contact between the effector (NK cell) and the target cells (infected macrophages) is essential in this system since, cell free supernatant generated after coculturing of effector cells with infected target cells fails to elicit any antileishmanial effect. Although NK cells from allogeneic mouse are strongly attached to the infected macrophages but unable to kill it in such interaction. The antileishmanial effect of allogeneic NK cells is mediated by TNF-alpha and not by IFN-gamma In vivo cellular therapy of established infection with NK cells from non-leishmania exposed allogeneic mouse significantly reduces the total parasite burden in the spleen of infected animal Crown Copyright (C) 2009 Published by Elsevier Ltd All rights reserved.
引用
收藏
页码：803 / 810
页数：8
相关论文
共 32 条
[1]   NEW PERSPECTIVES ON A SUBCLINICAL FORM OF VISCERAL LEISHMANIASIS [J].
BADARO, R ;
JONES, TC ;
CARVALHO, EM ;
SAMPAIO, D ;
REED, SG ;
BARRAL, A ;
TEIXEIRA, R ;
JOHNSON, WD .
JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (06) :1003-1011
[2]   Adoptive immunotherapy with donor lymphocyte infusions after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning [J].
Bethge, WA ;
Hegenbart, U ;
Stuart, MJ ;
Storer, BE ;
Maris, MB ;
Flowers, MED ;
Maloney, DG ;
Chauncey, T ;
Bruno, B ;
Agura, E ;
Forman, SJ ;
Blume, KG ;
Niederwieser, D ;
Storb, R ;
Sandmaier, BM .
BLOOD, 2004, 103 (03) :790-795
[3]  
BEUTLER B, 1993, CRIT CARE MED, V21, pS423
[4]   CELL-MEDIATED-IMMUNITY IN AMERICAN VISCERAL LEISHMANIASIS - REVERSIBLE IMMUNOSUPPRESSION DURING ACUTE INFECTION [J].
CARVALHO, EM ;
TEIXEIRA, RS ;
JOHNSON, WD .
INFECTION AND IMMUNITY, 1981, 33 (02) :498-502
[5]   ANTIGEN-SPECIFIC IMMUNOSUPPRESSION IN VISCERAL LEISHMANIASIS IS CELL-MEDIATED [J].
CARVALHO, EM ;
BACELLAR, O ;
BARRAL, A ;
BADARO, R ;
JOHNSON, WD .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (03) :860-864
[6]   Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation [J].
Childs, R ;
Chernoff, A ;
Contentin, N ;
Bahceci, E ;
Schrump, D ;
Leitman, S ;
Read, EJ ;
Tisdale, J ;
Dunbar, C ;
Linehan, WM ;
Young, NS ;
Barrett, AJ ;
Clave, E ;
Epperson, D ;
Mayo, V .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (11) :750-758
[7]  
CLERICI M, 1990, J IMMUNOL, V144, P3266
[8]  
Deckert-Schlüter M, 1998, J IMMUNOL, V160, P3427
[9]   Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 gene-deficient mice intravenously infected with Mycobacterium avium [J].
Ehlers, S ;
Benini, J ;
Kutsch, S ;
Endres, R ;
Rietschel, ET ;
Pfeffer, K .
INFECTION AND IMMUNITY, 1999, 67 (07) :3571-3579
[10]   TUMOR-NECROSIS-FACTOR-ALPHA IS REQUIRED IN THE PROTECTIVE IMMUNE-RESPONSE AGAINST MYCOBACTERIUM-TUBERCULOSIS IN MICE [J].
FLYNN, JL ;
GOLDSTEIN, MM ;
CHAN, J ;
TRIEBOLD, KJ ;
PFEFFER, K ;
LOWENSTEIN, CJ ;
SCHREIBER, R ;
MAK, TW ;
BLOOM, BR .
IMMUNITY, 1995, 2 (06) :561-572
1234