Influence of oxidative stress on the development of collateral circulation in total coronary occlusions

Objectives: The purpose of this study was to investigate whether the levels of total antioxidant capacity (TAC), total peroxide and oxidative stress index (OSI) are associated with the development of collaterals in total coronary occlusions. Design and methods: Our study group contained 176 consecutive men patients with single-vessel TCO, 94 of whom had poorly developed coronary collateral, while 82 had well-developed coronary collateral. TAC and total peroxide concentration were measured of plasma. The ratio of TAC to total peroxide was accepted as an indicator of oxidative stress. Results: The values of total peroxide and OSI in the Group I were significantly lower than that in Group II (p < 0.001, for both). TAC levels were significantly higher in patients with poorly developed collaterals than in well-developed collateral group (p < 0.001). OSI values were also significantly different among the Rentrop class-0, -1, -2 and -3 (ANOVA p < 0.001). We found significant correlations between collaterals score and TAC, total peroxide and OSI levels (p < 0.001 for all). In multiple linear regression analysis, total peroxide and OSI were independent predictors of collaterals score (p = 0.006 and p < 0.001 respectively). Conclusion: This study clearly demonstrates that the level of OSI is independently and positively associated with the presence of collateral circulation in total coronary occlusion patients. (c) 2006 Elsevier Ireland Ltd. All rights reserved.