SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype

被引：280

作者：

Mozos, Ana ^{[1
]}

Royo, Cristina ^{[1
]}

Hartmann, Elena ^{[2
]}

De Jong, Daphne ^{[3
]}

Baro, Cristina ^{[4
]}

Valera, Alexandra ^{[1
]}

Fu, Kai ^{[5
]}

Weisenburger, Dennis D. ^{[5
]}

Delabie, Jan ^{[6
]}

Chuang, Shih-Sung ^{[7
]}

Jaffe, Elaine S. ^{[8
]}

Ruiz-Marcellan, Carmen ^{[9
]}

Dave, Sandeep ^{[10
]}

Rimsza, Lisa ^{[11
]}

Braziel, Rita ^{[12
]}

Gascoyne, Randy D. ^{[13
]}

Sole, Francisco ^{[4
]}

Lopez-Guillermo, Armando ^{[1
]}

Colomer, Dolors ^{[1
]}

Staudt, Louis M. ^{[8
]}

Rosenwald, Andreas ^{[14
]}

Ott, German ^{[14
]}

Jares, Pedro ^{[1
]}

Campo, Elias ^{[1
]}

机构：

[1] Univ Barcelona, Dept Pathol & Hematol, Hematopathol Sect, Hosp Clin,IDIBAPS, E-08007 Barcelona, Spain

[2] Univ Wurzburg, Inst Pathol, D-8700 Wurzburg, Germany

[3] Antoni von Leevenhoek Hosp, Netherlands Canc Inst, Dept Pathol, Amsterdam, Netherlands

[4] Hosp del Mar, Dept Pathol, Lab Mol Cytogenet, Barcelona, Spain

[5] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA

[6] Norwegian Radium Hosp, Dept Pathol, Oslo, Norway

[7] Chi Mei Med Ctr, Dept Pathol, Tainan, Taiwan

[8] NCI, Sect Hematopathol & Lymphoma Clin Res, Ctr Canc Res, Div Canc Treatment & Diag,NIH, Bethesda, MD 20892 USA

[9] Autonomous Univ Barcelona, Vall Hebron Univ Hosp, Dept Pathol, E-08193 Barcelona, Spain

[10] Duke Univ, Duke Inst Genome Sci & Policy, Durham, NC USA

[11] Univ Arizona, Coll Med, Dept Pathol, Tucson, AZ 85721 USA

[12] Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA

[13] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada

[14] Robert Bosch Krankenhaus, Inst Klin Pathol, Stuttgart, Germany

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2009年 / 94卷 / 11期

关键词：

mantle cell lymphoma; cyclin D1; SOX11; ABERRANT EXPRESSION; GENE; PROFILES;

D O I：

10.3324/haematol.2009.010264

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors. Design and Methods The microarray database of 238 mature B-cell neoplasms was re-examined. SOX11 protein expression was investigated immunohistochemically in 12 cases of cyclin D1-negative mantle cell lymphoma, 54 cases of conventional mantle cell lymphoma, and 209 additional lymphoid neoplasms. Results SOX11 mRNA was highly expressed in conventional and cyclin D1-negative mantle cell lymphoma and in 33% of the cases of Burkitt's lymphoma but not in any other mature lymphoid neoplasm. SOX11 nuclear protein was detected in 50 cases (93%) of conventional mantle cell lymphoma and also in the 12 cyclin D1-negative cases of mantle cell lymphoma, the six cases of lymphoblastic lymphomas, in two of eight cases of Burkitt's lymphoma, and in two of three T-prolymphocytic leukemias but was negative in the remaining lymphoid neoplasms. Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative. The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantle cell lymphoma. Conclusions SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma.

引用

页码：1555 / 1562

页数：8

共 26 条

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