Strategies for Bone Regeneration: From Graft to Tissue Engineering

被引：189

作者：

Battafarano, Giulia ^{[1
]}

Rossi, Michela ^{[1
]}

De Martino, Viviana ^{[2
]}

Marampon, Francesco ^{[3
]}

Borro, Luca ^{[4
]}

Secinaro, Aurelio ^{[4
]}

Del Fattore, Andrea ^{[1
]}

机构：

[1] Bambino Gesu Pediat Hosp, Genet & Rare Dis Res Div, Bone Physiopathol Res Unit, IRCCS, I-00146 Rome, Italy

[2] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy

[3] Sapienza Univ Rome, Dept Radiotherapy, I-00161 Rome, Italy

[4] Bambino Gesu Pediat Hosp, Dept Imaging, Adv Cardiovasc Imaging Unit, IRCCS, I-00165 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 03期

关键词：

bone regeneration; tissue engineering; scaffolds; mesenchymal stem cell; bio-materials; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-DELIVERY; UMBILICAL-CORD BLOOD; MARROW STROMAL CELLS; OSTEOGENIC DIFFERENTIATION; COMPOSITE SCAFFOLDS; MECHANICAL-PROPERTIES; BIOACTIVE MATERIALS; CALVARIAL DEFECT; HYDROXYAPATITE;

D O I：

10.3390/ijms22031128

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone is a regenerative organ characterized by self-renewal ability. Indeed, it is a very dynamic tissue subjected to continuous remodeling in order to preserve its structure and function. However, in clinical practice, impaired bone healing can be observed in patients and medical intervention is needed to regenerate the tissue via the use of natural bone grafts or synthetic bone grafts. The main elements required for tissue engineering include cells, growth factors and a scaffold material to support them. Three different materials (metals, ceramics, and polymers) can be used to create a scaffold suitable for bone regeneration. Several cell types have been investigated in combination with biomaterials. In this review, we describe the options available for bone regeneration, focusing on tissue engineering strategies based on the use of different biomaterials combined with cells and growth factors.

引用

页码：1 / 22

页数：22

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