The basic reproductive ratio of life

被引：15

作者：

Manapat, Michael L. ^{[1
,2
]}

Chen, Irene A. ^{[3
]}

Nowak, Martin A. ^{[1
,4
,5
]}

机构：

[1] Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA

[2] MIT, Dept Math, Cambridge, MA 02139 USA

[3] Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA

[4] Harvard Univ, Dept Math, Cambridge, MA 02138 USA

[5] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2010年 / 263卷 / 03期

关键词：

Prelife; Replication; Template-directed synthesis; Evolutionary dynamics; IN-VITRO SELECTION; TEMPLATE-DIRECTED SYNTHESIS; PREBIOTIC CHEMISTRY; POPULATION BIOLOGY; RNA; EVOLUTION; ORIGIN; REPLICATION; MODEL; RIBONUCLEOTIDES;

D O I：

10.1016/j.jtbi.2009.12.020

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Template-directed polymerization of nucleotides is believed to be a pathway for the replication of genetic material in the earliest cells. We assume that activated monomers are produced by prebiotic chemistry. These monomers can undergo spontaneous polymerization, a system that we call "prelife." Adding template-directed polymerization changes the equilibrium structure of prelife if the rate constants meet certain criteria. In particular, if the basic reproductive ratio of sequences of a certain length exceeds one, then those sequences can attain high abundance. Furthermore, if many sequences replicate, then the longest sequences can reach high abundance even if the basic reproductive ratios of all sequences are less than one. We call this phenomenon "subcritical life." Subcritical life suggests that sequences long enough to be ribozymes can become abundant even if replication is relatively inefficient. Our work on the evolution of replication has interesting parallels to infection dynamics. Life (replication) can be seen as an infection of prelife. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：317 / 327

页数：11

共 79 条

[1]

ALLEN WILLIAM V., 1967, CURR MOD BIOL, V1, P24

[2] POPULATION BIOLOGY OF INFECTIOUS-DISEASES .1. [J].

ANDERSON, RM ;

MAY, RM .

NATURE, 1979, 280 (5721) :361-367

[3]

[Anonymous], 2006, EVOLUTIONARY DYNAMIC, DOI DOI 10.2307/J.CTVJGHW98

[4]

[Anonymous], 2000, VIRUS DYNAMICS

[5] ISOLATION OF NEW RIBOZYMES FROM A LARGE POOL OF RANDOM SEQUENCES [J].

BARTEL, DP ;

SZOSTAK, JW .

SCIENCE, 1993, 261 (5127) :1411-1418

[6] Planetary systems biology [J].

Benner, SA ;

Ricardo, A .

MOLECULAR CELL, 2005, 17 (04) :471-472

[7] Evolution - Planetary biology - Paleontological, geological, and molecular histories of life [J].

Benner, SA ;

Caraco, MD ;

Thomson, JM ;

Gaucher, EA .

SCIENCE, 2002, 296 (5569) :864-868

[8] Asymmetric autocatalysis and its implications for the origin of homochirality [J].

Blackmond, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (16) :5732-5736

[9] MUTATION AND THE EVOLUTION OF VIRULENCE [J].

BONHOEFFER, S ;

NOWAK, MA .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 258 (1352) :133-140

[10]

CAROTHERS JM, 2006, APTAMER HDB, P3

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