Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application

被引：33

作者：

Voltrova, Svatava ^{[1
]}

Muselli, Mickael ^{[1
]}

Filgas, Josef ^{[1
]}

Matousek, Vaclav ^{[2
]}

Klepetarova, Blanka ^{[1
]}

Beier, Petr ^{[1
]}

机构：

[1] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Namesti 2, Prague 16610, Czech Republic

[2] CF Plus Chem Sro, Kamenice 771-34, Brno 62500, Czech Republic

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 23期

关键词：

NUCLEOPHILIC TETRAFLUOROETHYLATION; ALKYNE CYCLOADDITION; LIQUID-CRYSTALS; TRIFLUOROMETHYLATION; ALPHA; ALPHA-DIFLUOROAZIDES; PERFLUOROALKYLATION; FLUOROALKYLATION; FLUORINATION; DERIVATIVES; CHEMISTRY;

D O I：

10.1039/c7ob01151b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrafluoroethylene-containing azides are accessed in two steps (one pot) from tetrafluoroalkyl bromides by metalation and reaction with electrophilic azides. Subsequent copper(I)-catalyzed azide-alkyne cycloaddition afforded N-tetrafluoroethyl and N-tetrafluoroethylene 4-substituted 1,2,3-triazoles. In addition, the protocol for the synthesis of 4,5-disubstituted 1,2,3-triazoles is presented.

引用

页码：4962 / 4965

页数：4

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