The present article aims to examine shape factor effects of SiO2/MoS2 hybrid nanoparticles suspended in ethylene glycol (EG) confined in a vertical rotating channel under the combined influence of mixed convection, thermal radiation, magnetohydodynamics, and periodic temperature. This study provides exact closed-form solutions for velocity and temperature distributions. Mathematical investigation is carried out by formulating the physical problem in Cartesian coordinates. Effect of significant emerging parameters is displayed and examined through graphs. It is concluded that the magnitude of velocity is higher in the case of small rotations than it is in the case of large rotations. It is noted that velocities upsurge for increasing values of the pressure gradient. The simple fluid has the lowest temperature distribution and the temperature is an increasing function of phi. Hybrid nanofluid having blade-like nanoparticles has a high temperature profile. Moreover, it is observed that temperature distribution is higher for SiO2/MoS2-EG hybrid nanofluid than for MoS2-EG nanofluid. Skin friction phase angle is a decreasing function of Omega, Gr, Re, and N while it is an increasing function of M and A. Magnitude of skin friction decreases with an increase in Omega, Re, M, N, and favorable pressure gradient; however, it increases with an increase in Gr. Nusselt number phase angle is an increasing function of N and phi(2) for SiO2/MoS2-EG hybrid nanofluid. Nusselt number amplitude is a decreasing function of N but it has an increasing trend for rising values of phi(2).