Studies on Ocimum gratissimum seed mucilage:: Evaluation of binding properties

Mucilage extracted from Ocimum gratissimum seeds, inertness and safety parameters established by a previous study was subjected to pre-formulation trial to assess its suitability as a pharmaceutical binder. Properties of the granules prepared with calcium carbonate using different concentrations of ocimum and compared with acacia (5%, w/w), as standard. Ocimum at 2.3% (w/w) level was found to be comparable with 5% (w/w) of acacia. Effect on drug release studied with paracetamol indicated that ocimum mucilage could be an alternative to acacia. (c) 2006 Elsevier B.V. All rights reserved.