Synthesis and antifungal activity of 1H-indole-4,7-diones

被引：51
作者：
Ryu, Chung-Kyu [1 ]
Lee, Jung Yoon [1 ]
Park, Rae-Eun [1 ]
Ma, Mi-Young [1 ]
Nho, Ji-Hee [1 ]
机构：
[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 01期
关键词：
1H-indole-4,7-dione; antimicrobial compounds; antifungal; fungi; substitution effects;
D O I：
10.1016/j.bmcl.2006.09.076
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1H-Indole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. The synthesized 1H-indole-4,7-diones generally showed good antifungal activity against Candida krusei, Cryptococcus neoformans, and Aspergillus niger. The results suggest that 1H-indole-4,7-diones would be potent antifungal agents. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：127 / 131
页数：5
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