The role of oxidative stress in amiodaron toxicity, in left ventricular dysfunction of hypertensive patients and in heart failure with preserved ejection fraction

Using in vitro biochemical, biophysical and in vivo animal research it was found that oxidative stress plays a substantial role in the pathogenesis of amiodarone toxicity and antioxidants co-administered with amiodarone exert at least partial protective effect on amiodarone toxicity, while antioxidants did not diminish and perhaps even enhanced the antiarrhythmic action of amiodarone. Thus, co-administration of antioxidants with amiodarone may lead to the more widespread application of amiodarone, which is currently the most potent available antiarrhythmic agent, but its clinical use is limited due the potentially severe toxic effect In hypertensive patients with normal ejection fraction, the most common precursor condition of heart failure with preserved ejection fraction, the potential primary causal role of oxidative stress and inflammation in the left ventricular systolic, diastolic and atrial dysfunction, which are important determinants of the transition of hypertensive heart disease to heart failure with preserved ejection fraction was verified.