SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

被引：178

作者：

Altmann, Daniel M. ^{[1
]}

Boyton, Rosemary J. ^{[2
,3
]}

机构：

[1] Imperial Coll, Dept Immunol & Inflammat, London W12 0NN, England

[2] Imperial Coll, Dept Infect Dis, London W12 0NN, England

[3] Royal Brompton & Harefield NHS Fdn Trust, Lung Div, London, England

来源：

SCIENCE IMMUNOLOGY | 2020年 / 5卷 / 49期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/sciimmunol.abd6160

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In efforts to synthesize a clear understanding of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) protective immunity, antibody analysis has been paralleled by T cell studies across asymptomatic, mild, and severe COVID-19 (coronavirus disease 2019). Defining CD4 and CD8 effector functions in protection is important, considering that antibody responses appear short-lived and T cell memory is potentially more durable. To fully understand population-level immunity, screening for both antibody and T cell immunity using standardized testing methods would be beneficial.

引用

页数：5

共 19 条

[1] SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 [J].

Braun, Julian ;

Loyal, Lucie ;

Frentsch, Marco ;

Wendisch, Daniel ;

Georg, Philipp ;

Kurth, Florian ;

Hippenstiel, Stefan ;

Dingeldey, Manuela ;

Kruse, Beate ;

Fauchere, Florent ;

Baysal, Emre ;

Mangold, Maike ;

Henze, Larissa ;

Lauster, Roland ;

Mall, Marcus A. ;

Beyer, Kirsten ;

Roehmel, Jobst ;

Voigt, Sebastian ;

Schmitz, Juergen ;

Miltenyi, Stefan ;

Demuth, Ilja ;

Mueller, Marcel A. ;

Hocke, Andreas ;

Witzenrath, Martin ;

Suttorp, Norbert ;

Kern, Florian ;

Reimer, Ulf ;

Wenschuh, Holger ;

Drosten, Christian ;

Corman, Victor M. ;

Giesecke-Thiel, Claudia ;

Sander, Leif Erik ;

Thiel, Andreas .

NATURE, 2020, 587 (7833) :270-+

[2]

Carfi A, 2020, JAMA

[3] SARS-CoV-2 infection protects against rechallenge in rhesus macaques [J].

Chandrashekar, Abishek ;

Liu, Jinyan ;

Martinot, Amanda J. ;

McMahan, Katherine ;

Mercado, Noe B. ;

Peter, Lauren ;

Tostanoski, Lisa H. ;

Yu, Jingyou ;

Maliga, Zoltan ;

Nekorchuk, Michael ;

Busman-Sahay, Kathleen ;

Terry, Margaret ;

Wrijil, Linda M. ;

Ducat, Sarah ;

Martinez, David R. ;

Atyeo, Caroline ;

Fischinger, Stephanie ;

Burke, John S. ;

Slein, Matthew D. ;

Pessaint, Laurent ;

Van Ry, Alex ;

Greenhouse, Jack ;

Taylor, Tammy ;

Blade, Kelvin ;

Cook, Anthony ;

Finneyfrock, Brad ;

Brown, Renita ;

Teow, Elyse ;

Velasco, Jason ;

Zahn, Roland ;

Wegmann, Frank ;

Abbink, Peter ;

Bondzie, Esther A. ;

Dagotto, Gabriel ;

Gebre, Makda S. ;

He, Xuan ;

Jacob-Dolan, Catherine ;

Kordana, Nicole ;

Li, Zhenfeng ;

Lifton, Michelle A. ;

Mahrokhian, Shant H. ;

Maxfield, Lori F. ;

Nityanandam, Ramya ;

Nkolola, Joseph P. ;

Schmidt, Aaron G. ;

Miller, Andrew D. ;

Baric, Ralph S. ;

Alter, Galit ;

Sorger, Peter K. ;

Estes, Jacob D. .

SCIENCE, 2020, 369 (6505) :812-+

[4] Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection [J].

Channappanavar, Rudragouda ;

Fett, Craig ;

Zhao, Jincun ;

Meyerholz, David K. ;

Perlman, Stanley .

JOURNAL OF VIROLOGY, 2014, 88 (19) :11034-11044

[5]

Gallais F., 2020, Methodes qualitatives, quantitatives et mixtes: dans la recherche en sciences humaines, sociales et de la Sante

[6] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [J].

Grifoni, Alba ;

Weiskopf, Daniela ;

Ramirez, Sydney, I ;

Mateus, Jose ;

Dan, Jennifer M. ;

Moderbacher, Carolyn Rydyznski ;

Rawlings, Stephen A. ;

Sutherland, Aaron ;

Premkumar, Lakshmanane ;

Jadi, Ramesh S. ;

Marrama, Daniel ;

de Silva, Aravinda M. ;

Frazier, April ;

Carlin, Aaron F. ;

Greenbaum, Jason A. ;

Peters, Bjoern ;

Krammer, Florian ;

Smith, Davey M. ;

Crotty, Shane ;

Sette, Alessandro .

CELL, 2020, 181 (07) :1489-+

[7] SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls [J].

Le Bert, Nina ;

Tan, Anthony T. ;

Kunasegaran, Kamini ;

Tham, Christine Y. L. ;

Hafezi, Morteza ;

Chia, Adeline ;

Chng, Melissa Hui Yen ;

Lin, Meiyin ;

Tan, Nicole ;

Linster, Martin ;

Chia, Wan Ni ;

Chen, Mark I-Cheng ;

Wang, Lin-Fa ;

Ooi, Eng Eong ;

Kalimuddin, Shirin ;

Tambyah, Paul Anantharajah ;

Low, Jenny Guek-Hong ;

Tan, Yee-Joo ;

Bertoletti, Antonio .

NATURE, 2020, 584 (7821) :457-+

[8] Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 [J].

Liao, Mingfeng ;

Liu, Yang ;

Yuan, Jing ;

Wen, Yanling ;

Xu, Gang ;

Zhao, Juanjuan ;

Cheng, Lin ;

Li, Jinxiu ;

Wang, Xin ;

Wang, Fuxiang ;

Liu, Lei ;

Amit, Ido ;

Zhang, Shuye ;

Zhang, Zheng .

NATURE MEDICINE, 2020, 26 (06) :842-+

[9] Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications [J].

Mathew, Divij ;

Giles, Josephine R. ;

Baxter, Amy E. ;

Oldridge, Derek A. ;

Greenplate, Allison R. ;

Wu, Jennifer E. ;

Alanio, Cecile ;

Kuri-Cervantes, Leticia ;

Pampena, M. Betina ;

D'Andrea, Kurt ;

Manne, Sasikanth ;

Chen, Zeyu ;

Huang, Yinghui Jane ;

Reilly, John P. ;

Weisman, Ariel R. ;

Ittner, Caroline A. G. ;

Kuthuru, Oliva ;

Dougherty, Jeanette ;

Nzingha, Kito ;

Han, Nicholas ;

Kim, Justin ;

Pattekar, Ajinkya ;

Goodwin, Eileen C. ;

Anderson, Elizabeth M. ;

Weirick, Madison E. ;

Gouma, Sigrid ;

Arevalo, Claudia P. ;

Bolton, Marcus J. ;

Chen, Fang ;

Lacey, Simon F. ;

Ramage, Holly ;

Cherry, Sara ;

Hensley, Scott E. ;

Apostolidis, Sokratis A. ;

Huang, Alexander C. ;

Vella, Laura A. ;

Betts, Michael R. ;

Meyer, Nuala J. ;

Wherry, E. John .

SCIENCE, 2020, 369 (6508) :1209-+

[10]

Meckiff Benjamin J, 2020, SSRN, P3641939, DOI [10.1101/2020.06.12.148916, 10.2139/ssrn.3641939]

← 1 2 →