Combination of structure-based design and combinatorial chemistry for the development of cathepsin D inhibitors.

被引:0
|
作者
Kick, EK
Roe, DC
Skillman, AD
Liu, GC
Ewing, TJA
Sun, YX
Kuntz, ID
Ellman, JA
机构
[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720
[2] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:67 / ORGN
页数:1
相关论文
共 50 条
  • [1] Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D
    Kick, EK
    Roe, DC
    Skillman, AG
    Liu, GC
    Ewing, TJA
    Sun, YX
    Kuntz, ID
    Ellman, JA
    CHEMISTRY & BIOLOGY, 1997, 4 (04): : 297 - 307
  • [2] STRUCTURE-BASED DRUG DESIGN OF A NOVEL SERIES OF HUMAN CATHEPSIN D INHIBITORS.
    Lee, Angela Y.
    Majer, Pavel
    Gulnik, Sergei V.
    Collins, Jack
    Silva, Abelardo M.
    Bhat, Narayana T.
    Erickson, John W.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996, 52 : C205 - C205
  • [3] Structure-based design of orally bioavailable cathepsin K inhibitors.
    Thompson, SK
    Michaud, E
    Halbert, SM
    Tomaszek, TA
    Tew, DG
    Zhao, BG
    Smith, WW
    Janson, CA
    D'Alessio, KJ
    McQueney, MS
    Kurdyla, J
    Jones, CS
    Abdel-Meguid, SS
    Ijames, CF
    DesJarlais, RL
    Salyers, KL
    Smith, BR
    Levy, MA
    Veber, DF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U1157 - U1157
  • [4] STRUCTURE-BASED DESIGN OF CALCINEURIN INHIBITORS.
    Kissinger, Charles R.
    Parge, Hans
    Knighton, Daniel
    Pelletier, Laura
    Tempczyk, Anna
    Tatlock, John
    Villafranca, Ernest
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996, 52 : C201 - C201
  • [5] Structure-based design of ricin inhibitors.
    Kerwin, SM
    Ravikumar, KS
    Miller, D
    Robertus, J
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U54 - U54
  • [6] Structure-based combinatorial libraries to identify potent inhibitors of cathepsin D.
    Kick, EK
    Roe, DC
    Skillman, AG
    Liu, GC
    Lee, CE
    Kuntz, ID
    Ellman, JA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 126 - MEDI
  • [7] Development of Cathepsin Inhibitors and Structure-Based Design of Cathepsin B-Specific Inhibitor
    Tomoo, Koji
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2010, 10 (07) : 696 - 707
  • [8] Structure-based drug design of HIV protease inhibitors.
    Navia, MA
    Tung, RD
    Chaturvedi, PR
    Rao, BG
    Partaledis, JA
    Kim, EE
    FASEB JOURNAL, 1996, 10 (06): : 2436 - 2436
  • [9] Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry
    Mondal, Milon
    Radeva, Nedyalka
    Koester, Helene
    Park, Ahyoung
    Potamitis, Constantinos
    Zervou, Maria
    Klebe, Gerhard
    Hirsch, Anna K. H.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (12) : 3259 - 3263
  • [10] The interplay between structure-based design and combinatorial chemistry
    Rupasinghe, Chamila N.
    Spaller, Mark R.
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2006, 10 (03) : 188 - 193