miR-10 in development and cancer

被引：131

作者：

Lund, A. H. ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark

[2] Univ Copenhagen, Ctr Epigenet, DK-2200 Copenhagen, Denmark

来源：

CELL DEATH AND DIFFERENTIATION | 2010年 / 17卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

microRNA; miR-10; miR-10a; Hox genes; cancer; 5 ' TOP; TOP MESSENGER-RNAS; MICRORNA EXPRESSION; C-MYC; PROTEIN; TRANSLATION; TARGET; GENES; EVOLUTION; BINDS; DIFFERENTIATION;

D O I：

10.1038/cdd.2009.58

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts. In addition, members of the miR-10 family are de-regulated in several cancer forms. Aside from acting in translational repression, miR-10 was recently found to bind a group of transcripts containing a terminal oligo-pyrimidine (TOP) motif and to induce their translation, thereby adding a new function to the miRNA repertoire. Cell Death and Differentiation (2010) 17, 209-214; doi: 10.1038/cdd.2009.58; published online 22 May 2009

引用

页码：209 / 214

页数：6

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