Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose

被引：31
|
作者：
Prudent, Julien [1 ]
McBride, Heidi M. [1 ]
机构：
[1] McGill Univ, Montreal Neurol Inst, 3801 Univ Ave, Montreal, PQ H3A 2B4, Canada
来源：
CURRENT BIOLOGY | 2016年 / 26卷 / 05期
关键词：
MAMMALIAN-CELLS; FISSION MACHINERY; MFF; RECRUITMENT; MID49; MID51; FIS1;
D O I：
10.1016/j.cub.2016.01.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drp1 is an oligomeric GTPase essential for mitochondrial division. A recent study has proposed a new model whereby machinery localized to the endoplasmic reticulum drives polymerization of actin, which then acts as a platform for Drp1 oligomerization and hydrolysis at mitochondrial constriction sites.
引用
收藏
页码：R207 / R209
页数：3
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