NEURON-GLIA INTERACTIONS Astroglial networks: a step further in neuroglial and gliovascular interactions

被引:564
作者
Giaume, Christian [1 ]
Koulakoff, Annette [1 ]
Roux, Lisa [1 ]
Holcman, David [2 ]
Rouach, Nathalie [1 ]
机构
[1] Coll France, INSERM, U840, F-75005 Paris, France
[2] Ecole Normale Super, Dept Biol & Math, F-75005 Paris, France
关键词
ASTROCYTIC GAP-JUNCTIONS; CULTURED ASTROCYTES; SPINAL-CORD; SYNAPTIC-TRANSMISSION; ELECTROPHYSIOLOGICAL PROPERTIES; HIPPOCAMPAL ASTROCYTES; CONNEXIN43; EXPRESSION; EPILEPTIFORM ACTIVITY; POSTNATAL-DEVELOPMENT; GLUCOSE-UTILIZATION;
D O I
10.1038/nrn2757
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dynamic aspects of interactions between astrocytes, neurons and the vasculature have recently been in the neuroscience spotlight. It has emerged that not only neurons but also astrocytes are organized into networks. Whereas neuronal networks exchange information through electrical and chemical synapses, astrocytes are interconnected through gap junction channels that are regulated by extra- and intracellular signals and allow exchange of information. This intercellular communication between glia has implications for neuroglial and gliovascular interactions and hence has added another level of complexity to our understanding of brain function.
引用
收藏
页码:87 / 99
页数:13
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