MicroRNA expression and function in cancer

被引：716
作者：
Garzon, Ramiro [1 ]
Fabbri, Muller [1 ]
Cimmino, Amelia [1 ]
Calin, George A. [1 ]
Croce, Carlo M. [1 ]
机构：
[1] Ohio State Univ, Dept Virol, Immunol & Human Genet & Comprehens Canc Ctr, Columbus, OH 43210 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2006年 / 12卷 / 12期
关键词：
D O I：
10.1016/j.molmed.2006.10.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs are small non-coding RNAs of 19-24 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and development. Recent work supports a role for miRNAs in the initiation and progression of human malignancies. Large high-throughput studies in patients revealed that miRNA profiling have the potential to classify tumors with high accuracy and predict outcome. Functional studies, some of which involve animal models, indicate that miRNAs act as tumor suppressors and oncogenes. Here, we summarize miRNA-profiling studies in human malignancies and examine the role of miRNAs in the pathogenesis of cancer. We also discuss the implications of these findings for the diagnosis and treatment of cancer.
引用
收藏
页码：580 / 587
页数：8
相关论文
共 68 条
[11]   MicroRNA-cancer connection: The beginning of a new tale [J].
Calin, George Adrian ;
Croce, Carlo Maria .
CANCER RESEARCH, 2006, 66 (15) :7390-7394
[12]   MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].
Chan, JA ;
Krichevsky, AM ;
Kosik, KS .
CANCER RESEARCH, 2005, 65 (14) :6029-6033
[13]   MicroRNAs modulate hematopoietic lineage differentiation [J].
Chen, CZ ;
Li, L ;
Lodish, HF ;
Bartel, DP .
SCIENCE, 2004, 303 (5654) :83-86
[14]   Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis [J].
Cheng, AM ;
Byrom, MW ;
Shelton, J ;
Ford, LP .
NUCLEIC ACIDS RESEARCH, 2005, 33 (04) :1290-1297
[15]   Extensive modulation of a set of microRNAs in primary glioblastoma [J].
Ciafrè, SA ;
Galardi, S ;
Mangiola, A ;
Ferracin, M ;
Liu, CG ;
Sabatino, G ;
Negrini, M ;
Maira, G ;
Croce, CM ;
Farace, MG .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (04) :1351-1358
[16]   miR-15 and miR-16 induce apoptosis by targeting BCL2 [J].
Cimmino, A ;
Calin, GA ;
Fabbri, M ;
Iorio, MV ;
Ferracin, M ;
Shimizu, M ;
Wojcik, SE ;
Aqeilan, RI ;
Zupo, S ;
Dono, M ;
Rassenti, L ;
Alder, H ;
Volinia, S ;
Liu, CG ;
Kipps, TJ ;
Negrini, M ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :13944-13949
[17]   Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice [J].
Costinean, S ;
Zanesi, N ;
Pekarsky, Y ;
Tili, E ;
Volinia, S ;
Heerema, N ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7024-7029
[18]   The brave new world of RNA [J].
Dennis, C .
NATURE, 2002, 418 (6894) :122-124
[19]   Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer [J].
Dong, JT ;
Boyd, JC ;
Frierson, HF .
PROSTATE, 2001, 49 (03) :166-171
[20]   Delineation of the minimal region of loss at 13q14 in multiple myeloma [J].
Elnenaei, MO ;
Hamoudi, RA ;
Swansbury, J ;
Gruszka-Westwood, AM ;
Brito-Babapulle, V ;
Matutes, E ;
Catovsky, D .
GENES CHROMOSOMES & CANCER, 2003, 36 (01) :99-106
1234567