Dual Role of Parathyroid Hormone in Endothelial Progenitor Cells and Marrow Stromal Mesenchymal Stem Cells

被引：21

作者：

Di Bernardo, Giovanni ^{[1
]}

Galderisi, Umberto ^{[1
,2
]}

Fiorito, Carmela ^{[3
]}

Squillaro, Tiziana

Cito, Letizia ^{[5
]}

Cipollaro, Marilena ^{[1
]}

Giordano, Antonio ^{[2
,4
,5
]}

Napoli, Claudio ^{[2
,6
]}

机构：

[1] Univ Naples 2, Dept Expt Med, Biotechnol & Mol Biol Sect, Naples, Italy

[2] Temple Univ, Ctr Biotechnol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA

[3] IRCCS Multimed, Milan, Italy

[4] Univ Siena, Human Pathol & Oncol Dept, I-53100 Siena, Italy

[5] Ctr Ric Oncol Mercogliano, Mercogliano, AV, Italy

[6] Univ Naples 2, Dept Gen Pathol, Naples, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 222卷 / 02期

关键词：

REPAIR; DIFFERENTIATION; EXPRESSION; NICHE; GENE; MOBILIZATION; MARKERS; PTH;

D O I：

10.1002/jcp.21976

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hematopoietic stem cells derive regulatory information also from parathyroid hormone (PTH). To explore the possibility that PTH may have a role in regulation of other stem cells residing in bone marrow, such as mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) we assessed the effect of this hormone on the in vitro behavior of MSCs and EPCs. We evidenced that MSCs were much more responsive to PTH than EPCs. PTH increased the proliferation rate of MSCs with a diminution of senescence and apoptosis. Taken together, our results may suggest a protective effect of PTH on MSCs that reduces stress phenomena and preserve genome integrity. At the opposite, PTH did not modify the fate of EPCs in culture. J. Cell. Physiol. 222: 474-480, 2010. (C) 2009 Wiley-Liss, Inc.

引用

页码：474 / 480

页数：7

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