Dual Role of Parathyroid Hormone in Endothelial Progenitor Cells and Marrow Stromal Mesenchymal Stem Cells

被引：20

作者：

Di Bernardo, Giovanni ^{[1
]}

Galderisi, Umberto ^{[1
,2
]}

Fiorito, Carmela ^{[3
]}

Squillaro, Tiziana

Cito, Letizia ^{[5
]}

Cipollaro, Marilena ^{[1
]}

Giordano, Antonio ^{[2
,4
,5
]}

Napoli, Claudio ^{[2
,6
]}

机构：

[1] Univ Naples 2, Dept Expt Med, Biotechnol & Mol Biol Sect, Naples, Italy

[2] Temple Univ, Ctr Biotechnol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA

[3] IRCCS Multimed, Milan, Italy

[4] Univ Siena, Human Pathol & Oncol Dept, I-53100 Siena, Italy

[5] Ctr Ric Oncol Mercogliano, Mercogliano, AV, Italy

[6] Univ Naples 2, Dept Gen Pathol, Naples, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 222卷 / 02期

关键词：

REPAIR; DIFFERENTIATION; EXPRESSION; NICHE; GENE; MOBILIZATION; MARKERS; PTH;

D O I：

10.1002/jcp.21976

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hematopoietic stem cells derive regulatory information also from parathyroid hormone (PTH). To explore the possibility that PTH may have a role in regulation of other stem cells residing in bone marrow, such as mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) we assessed the effect of this hormone on the in vitro behavior of MSCs and EPCs. We evidenced that MSCs were much more responsive to PTH than EPCs. PTH increased the proliferation rate of MSCs with a diminution of senescence and apoptosis. Taken together, our results may suggest a protective effect of PTH on MSCs that reduces stress phenomena and preserve genome integrity. At the opposite, PTH did not modify the fate of EPCs in culture. J. Cell. Physiol. 222: 474-480, 2010. (C) 2009 Wiley-Liss, Inc.

引用

页码：474 / 480

页数：7

共 38 条

[1] Phase I trial of parathyroid hormone to facilitate stem cell mobilization
Ballen, Karen K.
Shpall, Elizabeth J.
Avigan, David
Yeap, Beow Y.
Fisher, David C.
McDermott, Kathleen
Dey, Bimalangshu R.
Attar, Eyal
McAfee, Steven
Konopleva, Marina
Antin, Joseph H.
Spitzer, Thomas R.
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (07) : 838 - 843
[2] Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow
Brunner, Stefan
Zaruba, Marc-Michael
Huber, Bruno
David, Robert
Vallaster, Marcus
Assmann, Gerald
Mueller-Hoecker, Josef
Franz, Wolfgang-Michael
[J]. EXPERIMENTAL HEMATOLOGY, 2008, 36 (09) : 1157 - 1166
[3] Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells
Brunner, Stefan
Theiss, Hans Diogenes
Murr, Alfons
Negele, Thomas
Franz, Wolfgang-Michael
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (06): : E1670 - E1675
[4] Cellular senescence: when bad things happen to good cells
Campisi, Judith
di Fagagna, Fabrizio d'Adda
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (09) : 729 - 740
[5] The retinoblastoma gene is involved in multiple aspects of stem cell biology
Galderisi, U.
Cipollaro, M.
Giordano, A.
[J]. ONCOGENE, 2006, 25 (38) : 5250 - 5256
[6] Galderisi U, 1999, J CELL BIOCHEM, V73, P97, DOI 10.1002/(SICI)1097-4644(19990401)73:1<97::AID-JCB11>3.0.CO
[7] 2-M
[8] The complexity of p53 modulation: emerging patterns from divergent signals
Giaccia, AJ
Kastan, MB
[J]. GENES & DEVELOPMENT, 1998, 12 (19) : 2973 - 2983
[9] From the laboratory bench to the patients bedside: An update on clinical trials with mesenchymal stem cells
Giordano, Antonio
Galderisi, Umberto
Marino, Ignazio R.
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 211 (01) : 27 - 35
[10] Assessing identity, phenotype, and fate of endothelial progenitor cells
Hirschi, Karen K.
Ingram, David A.
Yoder, Mervin C.
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (09) : 1584 - 1595

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