Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

被引：26

作者：

Kraal, Kathelijne ^{[1
,2
]}

Blom, Thomas ^{[1
]}

van Noesel, Max ^{[1
]}

Kremer, Leontien ^{[2
]}

Caron, Huib ^{[2
]}

Tytgat, Godelieve ^{[1
,2
]}

van der Pal, Heleen ^{[3
]}

机构：

[1] Princess Maxima Ctr Pediat Oncol, Lundlaan 6, NL-3584 EA Utrecht, Netherlands

[2] Emma Childrens Hosp, Dept Pediat Oncol, Acad Med Ctr, Amsterdam, Netherlands

[3] Acad Med Ctr AMC, Dept Med Oncol, Amsterdam, Netherlands

来源：

PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 08期

关键词：

intraspinal extension; late effects; long-term health problems; neuroblastoma; spinal cord compression; systematic review; SPINAL-CORD COMPRESSION; CHILDHOOD-CANCER; MARROW-TRANSPLANTATION; IDIOPATHIC SCOLIOSIS; II NEUROBLASTOMA; RESIDUAL DISEASE; NEURO-BLASTOMA; FRENCH-SOCIETY; CHILDREN; RADIATION;

D O I：

10.1002/pbc.26451

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension. More well-designed, prospective studies are needed to determine the optimal treatment strategy.

引用

页数：12

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