ACE2 as therapy for glomerular disease: the devil is in the detail

被引：13

作者：

Ross, Michael J. ^{[1
]}

Nangaku, Masaomi ^{[2
]}

机构：

[1] Albert Einstein Coll Med, Div Nephrol, 1300 Morris Pk Ave,Ullmann 615-C, Bronx, NY 10461 USA

[2] Univ Tokyo, Sch Med, Div Nephrol & Endocrinol, Tokyo, Japan

来源：

KIDNEY INTERNATIONAL | 2017年 / 91卷 / 06期

关键词：

CONVERTING ENZYME 2; NEPHROPATHY;

D O I：

10.1016/j.kint.2017.04.001

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.

引用

页码：1269 / 1271

页数：3

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