Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N′-(2-alkynylbenzylidene)hydrazides

被引：53
作者：
Chen, Zhiyuan [1 ]
Su, Mingchao [1 ]
Yu, Xingxin [1 ]
Wu, Jie [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 22期
基金：
中国国家自然科学基金;
关键词：
CROSS-COUPLING REACTIONS; ORGANIC-SYNTHESIS; CASCADE REACTIONS; DOMINO REACTIONS; TANDEM REACTION; CYCLIZATION; ACCESS; WATER; 2-ALKYNYLBENZALDEHYDES; QUINOLIN-2(1H)-ONES;
D O I：
10.1039/b914265g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.
引用
收藏
页码：4641 / 4646
页数：6
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