Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N′-(2-alkynylbenzylidene)hydrazides

被引：53

作者：

Chen, Zhiyuan ^{[1
]}

Su, Mingchao ^{[1
]}

Yu, Xingxin ^{[1
]}

Wu, Jie ^{[1
,2
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 22期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; ORGANIC-SYNTHESIS; CASCADE REACTIONS; DOMINO REACTIONS; TANDEM REACTION; CYCLIZATION; ACCESS; WATER; 2-ALKYNYLBENZALDEHYDES; QUINOLIN-2(1H)-ONES;

D O I：

10.1039/b914265g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.

引用

页码：4641 / 4646

页数：6

共 37 条

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