Synthesis of cinnolines via Rh(III)-catalysed dehydrogenative C-H/N-H functionalization: aggregation induced emission and cell imaging

被引：64

作者：

Mayakrishnan, Sivakalai ^{[1
]}

Arun, Yuvaraj ^{[1
]}

Balachandran, Chandrasekar ^{[2
]}

Emi, Nobuhiko ^{[2
]}

Muralidharan, Doraiswamy ^{[1
]}

Perumal, Paramasivan Thirumalai ^{[1
]}

机构：

[1] Council Sci & Ind Res CSIR CLRI, Organ & Bioorgan Chem, Madras 600020, Tamil Nadu, India

[2] Fujita Hlth Univ, Dept Hematol, Toyoake, Aichi 4701192, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 06期

关键词：

SOLID-STATE FLUORESCENCE; BOND ACTIVATION; ALKYNES; ELECTROLUMINESCENCE; SEMICONDUCTORS; DERIVATIVES; LUMINOGENS; EMITTERS; OLEFINS; INDOLE;

D O I：

10.1039/c5ob02045j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.

引用

页码：1958 / 1968

页数：11

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