Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants

被引：132
作者：
Bozza, S
Gaziano, R
Lipford, GB
Montagnoli, C
Bacci, A
Di Francesco, P
Kurup, VP
Wagner, H
Romani, L
机构：
[1] Univ Perugia, Dept Expt Med & Biochem Sci, Microbiol Sect, I-06122 Perugia, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Microbiol Sect, Rome, Italy
[3] R&D Coley Pharmaceut, Langenfield, Germany
[4] Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-8000 Munich, Germany
[5] Med Coll Wisconsin, Div Allergy Immunol, Milwaukee, WI 53226 USA
[6] Vet Affairs Med Ctr, Milwaukee, WI 53295 USA
来源：
MICROBES AND INFECTION | 2002年 / 4卷 / 13期
关键词：
fungi; dendritic cells; vaccination;
D O I：
10.1016/S1286-4579(02)00007-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In a murine model of invasive pulmonary aspergillosis, dendritic cells (DCs) pulsed with Aspergillus antigens induced the activation of CD4(+) Th1 cells capable of conferring resistance to the infection. Here we show that the combined, local delivery of unmethylated CpG oligodeoxynucleotides (ODNs) and the Asp f 16 Aspergillus allergen resulted in the functional maturation and activation of airway DCs capable of inducing Th1 priming and resistance to the fungus. Therefore, ODNs act as a potent adjuvant for the vaccine-induced protection against the fungus by promoting dominant Th1 response to Aspergillus antigens and allergens. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：1281 / 1290
页数：10
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