Pancreatic Lipase Inhibitory Alkaloids of Murraya koenigii Leaves

被引：1

作者：

Birari, Rahul ^{[1
]}

Roy, Somendu Kumar ^{[1
]}

Singh, Anubha ^{[1
]}

Bhutani, Kamlesh Kumar ^{[1
]}

机构：

[1] NIPER, Dept Nat Prod, Sas Nagar 160062, Punjab, India

来源：

NATURAL PRODUCT COMMUNICATIONS | 2009年 / 4卷 / 08期

关键词：

Murraya koenigii; Rutaceae; pancreatic lipase; mahanimbin; koenimbin; koenigicine; clausazoline-K; obesity; CARBAZOLE ALKALOIDS; ANTIOBESITY; TARGETS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 2 1 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro. All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, koenigicine and clausazoline-K, with IC50 values of 17.9 mu M, 168.6 mu M, 428.6 mu M and <500 mu M, respectively. This study reports for the first time the PL inhibitory potential of carbazole alkaloids from plants.

引用

页码：1089 / 1092

页数：4

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