Facile synthesis of N-glycosyl amides using a N-glycosyl-2,4-dinitrobenzenesulfonamide and thioacids

被引：14
|
作者：
Talan, Rommel S. [1 ]
Sanki, Aditya K. [1 ]
Sucheck, Steven J. [1 ]
机构：
[1] Univ Toledo, Dept Chem, Toledo, OH 43606 USA
来源：
CARBOHYDRATE RESEARCH | 2009年 / 344卷 / 15期
关键词：
N-Glycosyl amide; N-Linked glycopeptides; N-Glycosylsulfonamide; N-Glycosyl asparagines; Convergent assembly; Amino thioacid; STAUDINGER LIGATION; 2,4-DINITROBENZENESULFONAMIDES; AZIDES; ACID;
D O I：
10.1016/j.carres.2009.07.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
N-Glucosyl-2,4-dinitrobenzenesulfonamide was prepared from N-acetyl-D-glucosamine and 2,4-dinitrobenzenesulfonyl chloride. Amidation of several thioacids using the N-glucosylsulfonamide donor proceeded smoothly to give the desired N-glucosylamides in good to high yields. The amidation reactions were carried out at room temperature, under mild conditions, and were completed in a very short time. Published by Elsevier Ltd.
引用
收藏
页码：2048 / 2050
页数：3
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