Indoleamine 2,3-dioxygenase in tumor induced tolerance

被引：18

作者：

Liu Xiao-qian ^{[1
]}

Wang Xin ^{[1
]}

机构：

[1] Shandong Univ, Dept Hematol, Prov Hosp, Jinan 250021, Shandong, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2009年 / 122卷 / 24期

关键词：

indoleamine 2,3-dioxygenase; immune tolerance; dendritic cells; regulatory T cells; 1-methyl-tryptophan; REGULATORY T-CELLS; PLASMACYTOID DENDRITIC CELLS; DRAINING LYMPH-NODES; TRYPTOPHAN CATABOLISM; BACTERIAL LIPOPOLYSACCHARIDE; INCREASED POPULATIONS; PERIPHERAL-BLOOD; IDO; INHIBITION; EXPRESSION;

D O I：

10.3760/cma.j.issn.0366-6999.2009.24.030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance. Data sources Published articles (1978-2009) on IDO and tumor induced tolerance were selected from Medline. Study selection Articles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose. Results Recent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells. Conclusion Up-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role. Chin Med J 2009,122(24):3072-3077

引用

页码：3072 / 3077

页数：6

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