Gold catalysis-facilitated rapid synthesis of the daphnane/tigliane tricyclic core

被引：30

作者：

Li, Yong ^{[1
,2
]}

Wei, Mufeng ^{[3
]}

Dai, Mingji ^{[1
,2
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Ctr Canc Res, W Lafayette, IN 47907 USA

[3] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

来源：

TETRAHEDRON | 2017年 / 73卷 / 29期

关键词：

Daphnane/tigliane; Diterpene; Gold catalysis; Furan formation; 4+3] cycloaddition; TIGLIANE RING-SYSTEM; PROTEIN-KINASE-C; TUMOR PROMOTERS; DAPHNANE DITERPENOIDS; PHORBOL SKELETON; IMDA APPROACH; ASYMMETRIC-SYNTHESIS; 1ST SYNTHESIS; CYCLOADDITION; CONSTRUCTION;

D O I：

10.1016/j.tet.2016.11.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise approach to synthesize the 5-7-6 tricyclic carbon skeleton of the daphnane/tigliane diterpene natural products has been accomplished via a sequential gold-catalyzed furan formation and furan-allene [4+3] cycloaddition. This work provides new avenues for rapid and diverted synthesis of the medicinally important daphnane/tigliane diterpenes and their unnatural analogs. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：4172 / 4177

页数：6