Two year sublingual immunotherapy affects serum leptin

被引：3

作者：

Ciprandi, Giorgio ^{[1
]}

De Amici, Mara ^{[2
]}

Tosca, Mariangela ^{[3
]}

Negrini, Simone ^{[1
]}

Murdaca, Giuseppe ^{[1
]}

Marseglia, Gian Luigi ^{[2
]}

机构：

[1] Univ Genoa, Dept Internal Med, Azienda Osped Univ San Martino, I-16126 Genoa, Italy

[2] Univ Pavia, Dept Pediat Sci, Pediat Clin, Fdn IRCCS San Matteo, I-27100 Pavia, Italy

[3] Ist Giannina Gaslini, Pneumol Allerg Dis Ctr, I-16148 Genoa, Italy

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2009年 / 9卷 / 10期

关键词：

Leptin; Allergic rhinitis; Gender; Sublingual immunotherapy; ALLERGIC RHINITIS; ADIPOKINES; ASTHMA; UPDATE;

D O I：

10.1016/j.intimp.2009.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: It has been demonstrated that serum leptin is elevated in females with allergic rhinitis. Recently, it has been reported that one course of sublingual immunotherapy (SLIT) does not affect serum leptin levels. Objective: The aim of this study was to evaluate the serum leptin levels in a cohort of patients with pollen-induced allergic rhinitis, before and after two pre-seasonal SLIT courses. Methods: Forty-one patients (22 males and 19 females, median age 39 years) with AR, due to pollen allergy, and 34 healthy subjects (16 males and 18 females, median age 43 years) were included in the study. Blood sampling for assessing serum leptin was performed in all subjects before and after the second SLIT course. Results: All patients were responders to SLIT Serum leptin was significantly increased only in males (p = 0.0056) after the second SLIT course. Conclusion: This preliminary study shows that at least two pre-seasonal SLIT courses were required to induce significant modifications in serum leptin levels, but it occurred only in males. Some hypotheses might be outlined, including a leptin protective effect, however further studies must clarify this issue. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1244 / 1246

页数：3

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