Last of the gem-Difluorocycloalkanes 2: Synthesis of Fluorinated Cycloheptane Building Blocks

被引：8

作者：

Herasymchuk, Maksym ^{[1
,2
]}

Melnykov, Kostiantyn P. ^{[1
,2
]}

Yarmoliuk, Dmytro V. ^{[1
]}

Serhiichuk, Dmytro ^{[1
]}

Rotar, Valeriia ^{[1
,3
]}

Pukhovoi, Timur ^{[1
,3
]}

Kuchkovska, Yuliya O. ^{[1
,2
]}

Holovach, Sergey ^{[1
,4
]}

Volochnyuk, Dmitriy M. ^{[1
,2
,4
]}

Ryabukhin, Sergey V. ^{[1
,2
]}

Grygorenko, Oleksandr O. ^{[1
,2
]}

机构：

[1] Enamine Ltd, Chervonotkatska St 78, UA-020941 Kiev, Ukraine

[2] Taras Shevchenko Natl Univ Kyiv, Volodymyrska St 60, UA-01601 Kiev, Ukraine

[3] Natl Tech Univ Ukraine, Igor Sikorsky Kyiv Polytech Inst, Prospect Peremogy 37, UA-03056 Kiev, Ukraine

[4] Natl Acad Sci Ukraine, Inst Organ Chem, Chervonotkatska St 78, UA-02094 Kiev, Ukraine

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 47期

关键词：

Fluorine; Cycloalkane; Cycloheptane; Deoxofluorination; Building blocks; BETA-KETO-ESTERS; RING-EXPANSION; PHARMACEUTICALS; CHEMISTRY; POLARITY;

D O I：

10.1002/ejoc.202001530

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The gem-difluorocycloalkane family was extended to all possible regioisomers of the gem-difluorocycloheptane, monofunctionalized by carboxilic-, amino- or keto- group, that were synthesized on a multigram scale. The preparation of the corresponding building blocks was achieved from readily accessible starting materials either via six-membered ring homologation or deoxofluorination of the appropriate seven-membered cyclic ketones.

引用

页码：6561 / 6569

页数：9

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